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Int. J. Mol. Sci. 2016, 17(2), 253; doi:10.3390/ijms17020253

Energy Metabolism Plays a Critical Role in Stem Cell Maintenance and Differentiation

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, First Affiliated Hospital, Zhejiang University, Hangzhou 310058, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Wilhelm Bloch
Received: 28 December 2015 / Revised: 29 January 2016 / Accepted: 15 February 2016 / Published: 18 February 2016
(This article belongs to the Special Issue Stem Cell Activation in Adult Organism)
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Various stem cells gradually turned to be critical players in tissue engineering and regenerative medicine therapies. Current evidence has demonstrated that in addition to growth factors and the extracellular matrix, multiple metabolic pathways definitively provide important signals for stem cell self-renewal and differentiation. In this review, we mainly focus on a detailed overview of stem cell metabolism in vitro. In stem cell metabolic biology, the dynamic balance of each type of stem cell can vary according to the properties of each cell type, and they share some common points. Clearly defining the metabolic flux alterations in stem cells may help to shed light on stemness features and differentiation pathways that control the fate of stem cells. View Full-Text
Keywords: glycolysis; mitochondria; oxidative phosphorylation; stem cells; regenerative medicine glycolysis; mitochondria; oxidative phosphorylation; stem cells; regenerative medicine

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Hu, C.; Fan, L.; Cen, P.; Chen, E.; Jiang, Z.; Li, L. Energy Metabolism Plays a Critical Role in Stem Cell Maintenance and Differentiation. Int. J. Mol. Sci. 2016, 17, 253.

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