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Int. J. Mol. Sci. 2016, 17(2), 208; doi:10.3390/ijms17020208

Argonaute and Argonaute-Bound Small RNAs in Stem Cells

1
Medical College, Hubei University of Arts and Science, Xiangyang 441053, Hubei, China
2
Xiangyang Oral Hospital, Xiangyang 441003, Hubei, China
3
Department of Neurosurgery, Medical School, the Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
4
Center for Stem Cell and Regenerative Medicine, the Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
5
Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA 95817, USA
6
Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children, Sacramento, CA 95817, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Cesar Borlongan
Received: 24 December 2015 / Revised: 28 January 2016 / Accepted: 1 February 2016 / Published: 4 February 2016
View Full-Text   |   Download PDF [1631 KB, uploaded 4 February 2016]   |  

Abstract

Small RNAs are essential for a variety of cellular functions. Argonaute (AGO) proteins are associated with all of the different classes of small RNAs, and are indispensable in small RNA-mediated regulatory pathways. AGO proteins have been identified in various types of stem cells in diverse species from plants and animals. This review article highlights recent progress on how AGO proteins and AGO-bound small RNAs regulate the self-renewal and differentiation of distinct stem cell types, including pluripotent, germline, somatic, and cancer stem cells. View Full-Text
Keywords: Argonaute; Piwi; small RNAs; stem cells Argonaute; Piwi; small RNAs; stem cells
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Zhai, L.; Wang, L.; Teng, F.; Zhou, L.; Zhang, W.; Xiao, J.; Liu, Y.; Deng, W. Argonaute and Argonaute-Bound Small RNAs in Stem Cells. Int. J. Mol. Sci. 2016, 17, 208.

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