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Int. J. Mol. Sci. 2016, 17(2), 176; doi:10.3390/ijms17020176

Melatonin Suppresses the Growth of Ovarian Cancer Cell Lines (OVCAR-429 and PA-1) and Potentiates the Effect of G1 Arrest by Targeting CDKs

1
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 807 Kaohsiung, Taiwan
2
Department of Gynecology and Obstetrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 807 Kaohsiung, Taiwan
3
Department of Obstetrics & Gynecology, E-Da Hospital, E-Da Hospital/I-Shou University, 82445 Kaohsiung, Taiwan
4
Graduate Institute of Medical Science, College of Health Sciences, Chang Jung Christian University, 71101 Tainan, Taiwan
5
Innovative Research Center of Medicine, College of Health Sciences, Chang Jung Christian University, 71101 Tainan, Taiwan
6
Division of Plastic Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 807 Kaohsiung, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Sanjay K. Srivastava
Received: 29 September 2015 / Revised: 11 January 2016 / Accepted: 18 January 2016 / Published: 29 January 2016
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [11612 KB, uploaded 29 January 2016]   |  

Abstract

Melatonin is found in animals as well as plants. In animals, it is a hormone that anticipates the daily onset of darkness and regulates physiological functions, such as sleep timing, blood pressure, and reproduction. Melatonin has also been found to have anti-tumor properties. Malignant cancers are the most common cause of death, and the mortality rate of ovarian tumor is the highest among gynecological diseases. This study investigated the anti-tumor effects of melatonin on the ovarian cancer lines, OVCAR-429 and PA-1. We observed the accumulation of melatonin-treated cells in the G1 phase due to the down-regulation of CDK 2 and 4. Our results suggest that in addition to the known effects on prevention, melatonin may also provide anti-tumor activity in established ovarian cancer. View Full-Text
Keywords: ovarian cancer; melatonin; cell cycle; CDK ovarian cancer; melatonin; cell cycle; CDK
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MDPI and ACS Style

Shen, C.-J.; Chang, C.-C.; Chen, Y.-T.; Lai, C.-S.; Hsu, Y.-C. Melatonin Suppresses the Growth of Ovarian Cancer Cell Lines (OVCAR-429 and PA-1) and Potentiates the Effect of G1 Arrest by Targeting CDKs. Int. J. Mol. Sci. 2016, 17, 176.

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