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Int. J. Mol. Sci. 2016, 17(2), 148; doi:10.3390/ijms17020148

Biodegradable Polymers Influence the Effect of Atorvastatin on Human Coronary Artery Cells

1
Department of Internal Medicine B (Cardiology), University Medicine Greifswald, Ferdinand-Sauerbruch-Strasse, 17475 Greifswald, Germany
2
DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine Greifswald, 17475 Greifswald, Germany
3
Institute of Pharmacology, University Medicine Greifswald, Felix-Hausdorff-Strasse 3, 17477 Greifswald, Germany
4
Faculty of Engineering and Informatics, Osnabrück University of Applied Sciences, Albrechtstrasse 30, 49076 Osnabrück, Germany
5
Research & Development, Aesculap AG, Am Aesculap Platz, 78532 Tuttlingen, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Antonella Piozzi
Received: 17 December 2015 / Revised: 14 January 2016 / Accepted: 18 January 2016 / Published: 22 January 2016
(This article belongs to the Section Biomaterial Sciences)
View Full-Text   |   Download PDF [2006 KB, uploaded 22 January 2016]   |  

Abstract

Drug-eluting stents (DES) have reduced in-stent-restenosis drastically. Yet, the stent surface material directly interacts with cascades of biological processes leading to an activation of cellular defense mechanisms. To prevent adverse clinical implications, to date almost every patient with a coronary artery disease is treated with statins. Besides their clinical benefit, statins exert a number of pleiotropic effects on endothelial cells (ECs). Since maintenance of EC function and reduction of uncontrolled smooth muscle cell (SMC) proliferation represents a challenge for new generation DES, we investigated the effect of atorvastatin (ATOR) on human coronary artery cells grown on biodegradable polymers. Our results show a cell type-dependent effect of ATOR on ECs and SMCs. We observed polymer-dependent changes in IC50 values and an altered ATOR-uptake leading to an attenuation of statin-mediated effects on SMC growth. We conclude that the selected biodegradable polymers negatively influence the anti-proliferative effect of ATOR on SMCs. Hence, the process of developing new polymers for DES coating should involve the characterization of material-related changes in mechanisms of drug actions. View Full-Text
Keywords: atorvastatin; poly(L-lactide); biodegradable polymer; human coronary artery endothelial cells; human coronary artery smooth muscle cells atorvastatin; poly(L-lactide); biodegradable polymer; human coronary artery endothelial cells; human coronary artery smooth muscle cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Strohbach, A.; Begunk, R.; Petersen, S.; Felix, S.B.; Sternberg, K.; Busch, R. Biodegradable Polymers Influence the Effect of Atorvastatin on Human Coronary Artery Cells. Int. J. Mol. Sci. 2016, 17, 148.

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