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Int. J. Mol. Sci. 2016, 17(12), 2115; doi:10.3390/ijms17122115

Maternal Food Restriction during Pregnancy and Lactation Adversely Affect Hepatic Growth and Lipid Metabolism in Three-Week-Old Rat Offspring

1
Department of Obstetrics and Gynecology and Ewha Medical Research Institute, Ewha Womans University Medical School, Seoul 07985, Korea
2
Department of Molecular Medicine and Ewha Medical Research Institute, Ewha Womans University Medical School, Seoul 07985, Korea
3
Department of Biochemistry, Ewha Womans University Medical School, Seoul 07985, Korea
4
Department of Molecular Medicine, Ewha Womans University Medical School, Seoul 07985, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Johannes Haybaeck
Received: 26 October 2016 / Revised: 2 December 2016 / Accepted: 11 December 2016 / Published: 15 December 2016
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [1549 KB, uploaded 15 December 2016]   |  

Abstract

Maternal malnutrition influences the early development of foetal adaptive changes for survival. We explored the effects of maternal undernutrition during gestation and lactation on hepatic growth and function. Sprague-Dawley rats were fed a normal or a food-restricted (FR) diet during gestation and/or lactation. We performed analyses of covariance (adjusting for the liver weight/body weight ratio) to compare hepatic growth and lipid metabolism among the offspring. Maternal FR during gestation triggered the development of wide spaces between hepatic cells and increased the expression of mammalian target of rapamycin (mTOR) in three-week-old male offspring compared with controls (both p < 0.05). Offspring nursed by FR dams exhibited wider spaces between hepatic cells and a lower liver weight/body weight ratio than control offspring, and increased mTOR expression (p < 0.05). Interestingly, the significant decrease in expression of lipogenic-related genes was dependent on carbohydrate-responsive element-binding protein, despite the increased expression of sterol regulatory element-binding protein 1 (SREBP1) (p < 0.05). This study demonstrated increased expression of key metabolic regulators (mTOR and SREBP1), alterations in lipid metabolism, and deficits in hepatic growth in the offspring of FR-treated dams. View Full-Text
Keywords: hepatic growth; lipid metabolism; male offspring; maternal food restriction hepatic growth; lipid metabolism; male offspring; maternal food restriction
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MDPI and ACS Style

Lee, S.; You, Y.-A.; Kwon, E.J.; Jung, S.-C.; Jo, I.; Kim, Y.J. Maternal Food Restriction during Pregnancy and Lactation Adversely Affect Hepatic Growth and Lipid Metabolism in Three-Week-Old Rat Offspring. Int. J. Mol. Sci. 2016, 17, 2115.

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