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Int. J. Mol. Sci. 2016, 17(12), 2094; doi:10.3390/ijms17122094

Genetic Variations Involved in Vitamin E Status

NORT, Aix-Marseille Université, INRA, INSERM, 13005 Marseille, France
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editors: Maria Laura Colombo, Laura Di Renzo and Rafat A. Siddiqui
Received: 12 October 2016 / Revised: 30 November 2016 / Accepted: 9 December 2016 / Published: 13 December 2016
(This article belongs to the Special Issue Tocopherols and Tocotrienols: Metabolism and Properties)
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Abstract

Vitamin E (VE) is the generic term for four tocopherols and four tocotrienols that exhibit the biological activity of α-tocopherol. VE status, which is usually estimated by measuring fasting blood VE concentration, is affected by numerous factors, such as dietary VE intake, VE absorption efficiency, and VE catabolism. Several of these factors are in turn modulated by genetic variations in genes encoding proteins involved in these factors. To identify these genetic variations, two strategies have been used: genome-wide association studies and candidate gene association studies. Each of these strategies has its advantages and its drawbacks, nevertheless they have allowed us to identify a list of single nucleotide polymorphisms associated with fasting blood VE concentration and α-tocopherol bioavailability. However, much work remains to be done to identify, and to replicate in different populations, all the single nucleotide polymorphisms involved, to assess the possible involvement of other kind of genetic variations, e.g., copy number variants and epigenetic modifications, in order to establish a reliable list of genetic variations that will allow us to predict the VE status of an individual by knowing their genotype in these genetic variations. Yet, the potential usefulness of this area of research is exciting with regard to personalized nutrition and for future clinical trials dedicated to assessing the biological effects of the various isoforms of VE. View Full-Text
Keywords: single nucleotide polymorphisms; genetic polymorphism; bioavailability; absorption; tocopherol; nutrigenetics; genome-wide association studies; candidate gene association studies; antioxidant; oxidative stress single nucleotide polymorphisms; genetic polymorphism; bioavailability; absorption; tocopherol; nutrigenetics; genome-wide association studies; candidate gene association studies; antioxidant; oxidative stress
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Borel, P.; Desmarchelier, C. Genetic Variations Involved in Vitamin E Status. Int. J. Mol. Sci. 2016, 17, 2094.

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