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Int. J. Mol. Sci. 2016, 17(12), 2041; doi:10.3390/ijms17122041

The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome System

370 Heritage Medical Research Center, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2S2, Canada
Department of Laboratory Medicine and Pathology (5B4. 09), University of Alberta, Edmonton, AB T6G 2B7, Canada
Author to whom correspondence should be addressed.
Academic Editor: Tomoo Iwakuma
Received: 1 October 2016 / Revised: 23 November 2016 / Accepted: 30 November 2016 / Published: 6 December 2016
(This article belongs to the Special Issue Emerging Non-Canonical Functions and Regulation of p53)
View Full-Text   |   Download PDF [1043 KB, uploaded 6 December 2016]   |  


The protein p63 has been identified as a homolog of the tumor suppressor protein p53 and is capable of inducing apoptosis, cell cycle arrest, or senescence. p63 has at least six isoforms, which can be divided into two major groups: the TAp63 variants that contain the N-terminal transactivation domain and the ΔNp63 variants that lack the N-terminal transactivation domain. The TAp63 variants are generally considered to be tumor suppressors involved in activating apoptosis and suppressing metastasis. ΔNp63 variants cannot induce apoptosis but can act as dominant negative inhibitors to block the function of TAp53, TAp73, and TAp63. p63 is rarely mutated in human tumors and is predominately regulated at the post-translational level by phosphorylation and ubiquitination. This review focuses primarily on regulation of p63 by the ubiquitin E-3 ligase family of enzymes via ubiquitination and proteasome-mediated degradation, and introduces a new key regulator of the p63 protein. View Full-Text
Keywords: p63; Mdm2; Mdm4; AIP 4; WWP1; E3 ligases; ubiquitination; degradation p63; Mdm2; Mdm4; AIP 4; WWP1; E3 ligases; ubiquitination; degradation

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Armstrong, S.R.; Wu, H.; Wang, B.; Abuetabh, Y.; Sergi, C.; Leng, R.P. The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome System. Int. J. Mol. Sci. 2016, 17, 2041.

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