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Int. J. Mol. Sci. 2016, 17(12), 2040; doi:10.3390/ijms17122040

HER2 Analysis in Sporadic Thyroid Cancer of Follicular Cell Origin

1
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Messina, AOU Policlinico G. Martino, 98125 Messina, Italy
2
Department of Biomedical Sciences and Morphological and Functional Images, Unit of Nuclear Medicine, University of Messina, AOU Policlinico G. Martino, 98125 Messina, Italy
3
Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, Unit of Pathological Anatomy, University of Messina, AOU Policlinico G. Martino, 98125 Messina, Italy
4
Department of Nuclear Medicine, Thyroid and PET/CT Center, Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Daniela Gabriele Grimm
Received: 7 November 2016 / Revised: 28 November 2016 / Accepted: 30 November 2016 / Published: 6 December 2016
(This article belongs to the Special Issue Current Knowledge in Thyroid Cancer—From Bench to Bedside)
View Full-Text   |   Download PDF [7177 KB, uploaded 6 December 2016]   |  

Abstract

The Epidermal Growth Factor Receoptor (EGFR) family member human epidermal growth factor receptor 2 (HER2) is overexpressed in many human epithelial malignancies, representing a molecular target for specific anti-neoplastic drugs. Few data are available on HER2 status in differentiated thyroid cancer (DTC). The present study was aimed to investigate HER2 status in sporadic cancers of follicular cell origin to better clarify the role of this receptor in the stratification of thyroid cancer. By immunohistochemistry and fluorescence in-situ hybridization, HER2 expression was investigated in formalin-fixed paraffin-embedded surgical specimens from 90 DTC patients, 45 follicular (FTC) and 45 papillary (PTC) histotypes. No HER2 immunostaining was recorded in background thyroid tissue. By contrast, overall HER2 overexpression was found in 20/45 (44%) FTC and 8/45 (18%) PTC, with a significant difference between the two histotypes (p = 0.046). Five of the six patients who developed metastatic disease during a median nine-year follow-up had a HER2-positive tumor. Therefore, we suggest that HER2 expression may represent an additional aid to identify a subset of patients who are characterized by a worse prognosis and are potentially eligible for targeted therapy. View Full-Text
Keywords: sporadic differentiated thyroid cancer; HER2 (Human Epidermal Growth Factor Receptor 2); immunohistochemistry; FISH (fluorescence in situ hybridization) sporadic differentiated thyroid cancer; HER2 (Human Epidermal Growth Factor Receptor 2); immunohistochemistry; FISH (fluorescence in situ hybridization)
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MDPI and ACS Style

Ruggeri, R.M.; Campennì, A.; Giuffrè, G.; Giovanella, L.; Siracusa, M.; Simone, A.; Branca, G.; Scarfì, R.; Trimarchi, F.; Ieni, A.; Tuccari, G. HER2 Analysis in Sporadic Thyroid Cancer of Follicular Cell Origin. Int. J. Mol. Sci. 2016, 17, 2040.

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