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Int. J. Mol. Sci. 2016, 17(12), 2068; doi:10.3390/ijms17122068

Non-Canonical Cell Death Induced by p53

Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
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Author to whom correspondence should be addressed.
Academic Editor: Charles A. Collyer
Received: 6 October 2016 / Revised: 30 November 2016 / Accepted: 6 December 2016 / Published: 9 December 2016
(This article belongs to the Special Issue Emerging Non-Canonical Functions and Regulation of p53)
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Abstract

Programmed cell death is a vital biological process for multicellular organisms to maintain cellular homeostasis, which is regulated in a complex manner. Over the past several years, apart from apoptosis, which is the principal mechanism of caspase-dependent cell death, research on non-apoptotic forms of programmed cell death has gained momentum. p53 is a well characterized tumor suppressor that controls cell proliferation and apoptosis and has also been linked to non-apoptotic, non-canonical cell death mechanisms. p53 impacts these non-canonical forms of cell death through transcriptional regulation of its downstream targets, as well as direct interactions with key players involved in these mechanisms, in a cell type- or tissue context-dependent manner. In this review article, we summarize and discuss the involvement of p53 in several non-canonical modes of cell death, including caspase-independent apoptosis (CIA), ferroptosis, necroptosis, autophagic cell death, mitotic catastrophe, paraptosis, and pyroptosis, as well as its role in efferocytosis which is the process of clearing dead or dying cells. View Full-Text
Keywords: apoptosis; caspase-independent apoptosis (CIA); ferroptosis; necroptosis; autophagy; mitotic catastrophe; paraptosis; pyroptosis; efferocytosis apoptosis; caspase-independent apoptosis (CIA); ferroptosis; necroptosis; autophagy; mitotic catastrophe; paraptosis; pyroptosis; efferocytosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ranjan, A.; Iwakuma, T. Non-Canonical Cell Death Induced by p53. Int. J. Mol. Sci. 2016, 17, 2068.

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