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Int. J. Mol. Sci. 2016, 17(12), 2037; doi:10.3390/ijms17122037

Integrins in the Spotlight of Cancer

Department of Internal Medicine I, Comprehensive Cancer Center Vienna, Medical University of Vienna, A-1090 Vienna, Austria
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Academic Editor: Anthony Lemarié
Received: 18 October 2016 / Revised: 17 November 2016 / Accepted: 28 November 2016 / Published: 6 December 2016
(This article belongs to the Special Issue Integrins in Cancer)
View Full-Text   |   Download PDF [2027 KB, uploaded 6 December 2016]   |  

Abstract

Integrins are heterodimeric cell surface receptors that bind to different extracellular ligands depending on their composition and regulate all processes which enable multicellular life. In cancer, integrins trigger and play key roles in all the features that were once described as the Hallmarks of Cancer. In this review, we will discuss the contribution of integrins to these hallmarks, including uncontrolled and limitless proliferation, invasion of tumor cells, promotion of tumor angiogenesis and evasion of apoptosis and resistance to growth suppressors, by highlighting the latest findings. Further on, given the paramount role of integrins in cancer, we will present novel strategies for integrin inhibition that are starting to emerge, promising a hopeful future regarding cancer treatment. View Full-Text
Keywords: integrins; cancer; proliferation; invasion; apoptosis; telomerase; angiogenesis; apoptosis; contact inhibition; locomotion integrins; cancer; proliferation; invasion; apoptosis; telomerase; angiogenesis; apoptosis; contact inhibition; locomotion
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Bianconi, D.; Unseld, M.; Prager, G.W. Integrins in the Spotlight of Cancer. Int. J. Mol. Sci. 2016, 17, 2037.

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