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Int. J. Mol. Sci. 2016, 17(12), 2042; doi:10.3390/ijms17122042

Nutraceutical Supplements in the Management and Prevention of Osteoarthritis

1
Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, 95100 Catania, Italy
2
Department of Clinical and Experimental Medicine, University of Catania, 95100 Catania, Italy
3
Department of Molecular and Cellular Biology and Plant Physiology, Centre of Biotechnology of Borj Cedreya, University of Carthage, Carthage 2050, Tunisia
*
Author to whom correspondence should be addressed.
Academic Editor: Irmgard Tegeder
Received: 19 October 2016 / Revised: 24 November 2016 / Accepted: 30 November 2016 / Published: 6 December 2016
(This article belongs to the Collection Feature Annual Reviews in Molecular Sciences)
View Full-Text   |   Download PDF [517 KB, uploaded 6 December 2016]   |  

Abstract

Nutraceuticals are dietary compounds which have a role in the balance of anabolic and catabolic signals in joints. Their regulatory function on homeostasis of cartilage metabolism nutraceuticals is increasingly considered for the management and, above all, the prevention of osteoarthritis (OA). OA is a degenerative disease characterized by cartilage and synovium inflammation that can cause joint stiffness, swelling, pain, and loss of mobility. It is a multifactorial disease and, due to the great percentage of people suffering from it and the general increase in life expectancy, OA is considered as one of the most significant causes of disability in the world. OA impairs the structural integrity of articular cartilage that greatly depends on a balance between the anabolic and catabolic processes which occur in chondrocytes and synovial fluid of the joints, therefore the integration with nutraceutical compounds in diet increases the treatment options for patients with established OA beyond traditional rehabilitation, medications, and surgical strategies. In our review, with respect to the current literature, we highlight some of many existing nutraceutical compounds that could be used as integrators in a daily diet thanks to their easy availability, such as in olive oil, fish oil, and botanical extracts used as non-pharmacologic treatment. View Full-Text
Keywords: nutraceuticals; osteoarthritis; prevention; diet nutraceuticals; osteoarthritis; prevention; diet
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Castrogiovanni, P.; Trovato, F.M.; Loreto, C.; Nsir, H.; Szychlinska, M.A.; Musumeci, G. Nutraceutical Supplements in the Management and Prevention of Osteoarthritis. Int. J. Mol. Sci. 2016, 17, 2042.

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