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Int. J. Mol. Sci. 2016, 17(12), 1976; doi:10.3390/ijms17121976

Applications of Alginate-Based Bioinks in 3D Bioprinting

Nanoscience Centre, Department of Engineering, Cambridge University, Cambridge CB3 0FF, UK
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Author to whom correspondence should be addressed.
Academic Editor: Hermann Ehrlich
Received: 5 October 2016 / Revised: 18 November 2016 / Accepted: 21 November 2016 / Published: 25 November 2016
(This article belongs to the Special Issue Frontiers of Marine Biomaterials)
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Abstract

Three-dimensional (3D) bioprinting is on the cusp of permitting the direct fabrication of artificial living tissue. Multicellular building blocks (bioinks) are dispensed layer by layer and scaled for the target construct. However, only a few materials are able to fulfill the considerable requirements for suitable bioink formulation, a critical component of efficient 3D bioprinting. Alginate, a naturally occurring polysaccharide, is clearly the most commonly employed material in current bioinks. Here, we discuss the benefits and disadvantages of the use of alginate in 3D bioprinting by summarizing the most recent studies that used alginate for printing vascular tissue, bone and cartilage. In addition, other breakthroughs in the use of alginate in bioprinting are discussed, including strategies to improve its structural and degradation characteristics. In this review, we organize the available literature in order to inspire and accelerate novel alginate-based bioink formulations with enhanced properties for future applications in basic research, drug screening and regenerative medicine. View Full-Text
Keywords: alginate; 3D bioprinting; bioink; tissue engineering alginate; 3D bioprinting; bioink; tissue engineering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Axpe, E.; Oyen, M.L. Applications of Alginate-Based Bioinks in 3D Bioprinting. Int. J. Mol. Sci. 2016, 17, 1976.

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