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Int. J. Mol. Sci. 2016, 17(11), 1922; doi:10.3390/ijms17111922

Transcriptome-Based Discovery of Fusarium graminearum Stress Responses to FgHV1 Infection

1
State Key Laboratory for Biology of Plant Disease and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Science, Beijing 100081, China
2
Walloon Centre of Industrial Biology, Gembloux Agro-Bio Tech, University of Liège, Passage des Déportés, 2, Gembloux 5030, Belgium
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Patrick C. Y. Woo
Received: 12 September 2016 / Revised: 25 October 2016 / Accepted: 11 November 2016 / Published: 17 November 2016
(This article belongs to the Special Issue Host-Microbe Interaction)
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Abstract

Fusarium graminearum hypovirus 1 (FgHV1), which is phylogenetically related to Cryphonectria hypovirus 1 (CHV1), is a virus in the family Hypoviridae that infects the plant pathogenic fungus F. graminearum. Although hypovirus FgHV1 infection does not attenuate the virulence of the host (hypovirulence), it results in defects in mycelial growth and spore production. We now report that the vertical transmission rate of FgHV1 through asexual spores reached 100%. Using RNA deep sequencing, we performed genome-wide expression analysis to reveal phenotype-related genes with expression changes in response to FgHV1 infection. A total of 378 genes were differentially expressed, suggesting that hypovirus infection causes a significant alteration of fungal gene expression. Nearly two times as many genes were up-regulated as were down-regulated. A differentially expressed gene enrichment analysis identified a number of important pathways. Metabolic processes, the ubiquitination system, and especially cellular redox regulation were the most affected categories in F. graminearum challenged with FgHV1. The p20, encoded by FgHV1 could induce H2O2 accumulation and hypersensitive response in Nicotiana benthamiana leaves. Moreover, hypovirus FgHV1 may regulate transcription factors and trigger the RNA silencing pathway in F. graminearum. View Full-Text
Keywords: Fusarium graminearum; Fusarium graminearum hypovirus 1; transcriptome; stress responses; cellular redox regulation Fusarium graminearum; Fusarium graminearum hypovirus 1; transcriptome; stress responses; cellular redox regulation
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MDPI and ACS Style

Wang, S.; Zhang, J.; Li, P.; Qiu, D.; Guo, L. Transcriptome-Based Discovery of Fusarium graminearum Stress Responses to FgHV1 Infection. Int. J. Mol. Sci. 2016, 17, 1922.

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