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Int. J. Mol. Sci. 2016, 17(11), 1919; doi:10.3390/ijms17111919

A Mixture of Extracts of Kochia scoparia and Rosa multiflora with PPAR α/γ Dual Agonistic Effects Prevents Photoaging in Hairless Mice

1
Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju 26426, Korea
2
Skin Research Team, Cosmax R&I Center, Seongnam 13486, Korea
3
Natural Skinomics Team, KIST Gangneung Institute of Natural Products, Gangneung 25451, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Chris Jackson
Received: 20 August 2016 / Revised: 30 October 2016 / Accepted: 7 November 2016 / Published: 16 November 2016
(This article belongs to the Special Issue Inflammatory Skin Conditions)
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Abstract

Activation of peroxisome proliferator-activated receptors (PPAR) α/γ is known to inhibit the increases in matrix metalloproteinase (MMP) and reactive oxygen species (ROS) induced by ultraviolet light (UV). Extracts of natural herbs, such as Kochia scoparia and Rosa multiflora, have a PPAR α/γ dual agonistic effect. Therefore, we investigated whether and how they have an antiaging effect on photoaging skin. Eighteen-week-old hairless mice were irradiated with UVA 14 J/cm2 and UVB 40 mJ/cm2 three times a week for 8 weeks. A mixture of extracts of Kochia scoparia and Rosa multiflora (KR) was topically applied on the dorsal skin of photoaging mice twice a day for 8 weeks. Tesaglitazar, a known PPAR α/γ agonist, and vehicle (propylene glycol:ethanol = 7:3, v/v) were applied as positive and negative controls, respectively. Dermal effects (including dermal thickness, collagen density, dermal expression of procollagen 1 and collagenase 13) and epidermal effects (including skin barrier function, epidermal proliferation, epidermal differentiation, and epidermal cytokines) were measured and compared. In photoaging murine skin, KR resulted in a significant recovery of dermal thickness as well as dermal fibroblasts, although it did not change dermal collagen density. KR increased the expression of dermal transforming growth factor (TGF)-β. The dermal effects of KR were explained by an increase in procollagen 1 expression, induced by TGF-β, and a decrease in MMP-13 expression. KR did not affect basal transepidermal water loss (TEWL) or stratum corneum (SC) integrity, but did decrease SC hydration. It also did not affect epidermal proliferation or epidermal differentiation. KR decreased the expression of epidermal interleukin (IL)-1α. Collectively, KR showed possible utility as a therapeutic agent for photoaging skin, with few epidermal side effects such as epidermal hyperplasia or poor differentiation. View Full-Text
Keywords: PPAR α/γ; photoaging; ultraviolet radiation; skin barrier; procollagen 1 PPAR α/γ; photoaging; ultraviolet radiation; skin barrier; procollagen 1
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Jeon, H.; Kim, D.H.; Nho, Y.-H.; Park, J.-E.; Kim, S.-N.; Choi, E.H. A Mixture of Extracts of Kochia scoparia and Rosa multiflora with PPAR α/γ Dual Agonistic Effects Prevents Photoaging in Hairless Mice. Int. J. Mol. Sci. 2016, 17, 1919.

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