Severe Cutaneous Adverse Reactions: The Pharmacogenomics from Research to Clinical Implementation
AbstractSevere cutaneous adverse reactions (SCARs), previously thought to be idiosyncratic or unpredictable, are a deadly form of adverse drug reactions with skin manifestations. Current pharmacogenomic studies of SCARs have made important strides, as the prevention of SCARs, to some extent, appears attainable with the identification of genetic variants for genes encoding drug-metabolizing enzymes and human leukocyte antigens (HLAs). Despite the improvement of incidence, a treatment guideline for this devastating condition is still unavailable, highlighting the inadequacy of contemporary accepted therapeutic interventions. As such, prompt withdrawal of causative drugs is believed to be a priority of patient management. In this review, we discuss recent cutting-edge findings concerning the discovery of biomarkers for SCARs and their clinical utilities in the better prediction and early diagnosis of this disease. The knowledge compiled herein provides clues for future investigations on deciphering additional genetic markers for SCARs and the design of clinical trials for the prospective identification of subjects at genetic risk for this condition, ultimately personalizing the medicine. View Full-Text
Share & Cite This Article
Su, S.-C.; Hung, S.-I.; Fan, W.-L.; Dao, R.-L.; Chung, W.-H. Severe Cutaneous Adverse Reactions: The Pharmacogenomics from Research to Clinical Implementation. Int. J. Mol. Sci. 2016, 17, 1890.
Su S-C, Hung S-I, Fan W-L, Dao R-L, Chung W-H. Severe Cutaneous Adverse Reactions: The Pharmacogenomics from Research to Clinical Implementation. International Journal of Molecular Sciences. 2016; 17(11):1890.Chicago/Turabian Style
Su, Shih-Chi; Hung, Shuen-Iu; Fan, Wen-Lang; Dao, Ro-Lan; Chung, Wen-Hung. 2016. "Severe Cutaneous Adverse Reactions: The Pharmacogenomics from Research to Clinical Implementation." Int. J. Mol. Sci. 17, no. 11: 1890.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.