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Int. J. Mol. Sci. 2016, 17(11), 1798; doi:10.3390/ijms17111798

Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum

Department of Biomedical Chemistry, Konkuk University, Chungju 27478, Korea
These authors contributed equally to this work.
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Academic Editor: Manickam Sugumaran
Received: 1 October 2016 / Revised: 21 October 2016 / Accepted: 25 October 2016 / Published: 27 October 2016
(This article belongs to the Special Issue Biochemistry and Mechanisms of Melanogenesis)
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Abstract

Ganoderma lucidum, a species of the Basidiomycetes class, has been attracting international attention owing to its wide variety of biological activities and great potential as an ingredient in skin care cosmetics including “skin-whitening” products. However, there is little information available on its inhibitory effect against tyrosinase activity. Therefore, the objectives of this study were to investigate the chemical composition of G. lucidum and its inhibitory effects on melanogenesis. We isolated the active compound from G. lucidum using ethanol extraction and ethyl acetate fractionation. In addition, we assayed its inhibitory effects on tyrosinase activity and melanin biosynthesis in B16F10 melanoma cells. In this study, we identified a bioactive compound, ganodermanondiol, which inhibits the activity and expression of cellular tyrosinase and the expression of tyrosinase-related protein-1 (TRP-1), TRP-2, and microphthalmia-associated transcription factor (MITF), thereby decreasing melanin production. Furthermore, ganodermanondiol also affected the mitogen-activated protein kinase (MAPK) cascade and cyclic adenosine monophosphate (cAMP)-dependent signaling pathway, which are involved in the melanogenesis of B16F10 melanoma cells. The finding that ganodermanondiol from G. lucidum exerts an inhibitory effect on tyrosinase will contribute to the use of this mushroom in the preparation of skin care products in the future. View Full-Text
Keywords: B16F10 melanoma cell; Ganoderma lucidum; ganodermanondiol; microphthalmia-associated transcription factor; tyrosinase; tyrosinase-related proteins B16F10 melanoma cell; Ganoderma lucidum; ganodermanondiol; microphthalmia-associated transcription factor; tyrosinase; tyrosinase-related proteins
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kim, J.-W.; Kim, H.-I.; Kim, J.-H.; Kwon, O.-C.; Son, E.-S.; Lee, C.-S.; Park, Y.-J. Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum. Int. J. Mol. Sci. 2016, 17, 1798.

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