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Int. J. Mol. Sci. 2016, 17(11), 1797; doi:10.3390/ijms17111797

The Activating NKG2C Receptor Is Significantly Reduced in NK Cells after Allogeneic Stem Cell Transplantation in Patients with Severe Graft-versus-Host Disease

1
Department of Bone Marrow Transplantation, University Hospital Essen, Essen 45147, Germany
2
Institute for Transfusion Medicine, University Hospital Essen, Essen 45147, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Muraca
Received: 31 July 2016 / Revised: 18 October 2016 / Accepted: 20 October 2016 / Published: 27 October 2016
(This article belongs to the Special Issue Advances in Cell Transplantation)
View Full-Text   |   Download PDF [1252 KB, uploaded 27 October 2016]   |  

Abstract

Natural killer (NK) cells play a central role in the innate immune system. In allogeneic stem cell transplantation (alloSCT), alloreactive NK cells derived by the graft are discussed to mediate the elimination of leukemic cells and dendritic cells in the patient and thereby to reduce the risk for leukemic relapses and graft-versus-host reactions. The alloreactivity of NK cells is determined by various receptors including the activating CD94/NKG2C and the inhibitory CD94/NKG2A receptors, which both recognize the non-classical human leukocyte antigen E (HLA-E). Here we analyze the contribution of these receptors to NK cell alloreactivity in 26 patients over the course of the first year after alloSCT due to acute myeloid leukemia, myelodysplastic syndrome and T cell Non-Hodgkin-Lymphoma. Our results show that NK cells expressing the activating CD94/NKG2C receptor are significantly reduced in patients after alloSCT with severe acute and chronic graft-versus-host disease (GvHD). Moreover, the ratio of CD94/NKG2C to CD94/NKG2A was reduced in patients with severe acute and chronic GvHD after receiving an HLA-mismatched graft. Collectively, these results provide evidence for the first time that CD94/NKG2C is involved in GvHD prevention. View Full-Text
Keywords: allogeneic stem cell transplantation; graft-versus-host disease; NK cells; NKG2C receptor allogeneic stem cell transplantation; graft-versus-host disease; NK cells; NKG2C receptor
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MDPI and ACS Style

Kordelas, L.; Steckel, N.-K.; Horn, P.A.; Beelen, D.W.; Rebmann, V. The Activating NKG2C Receptor Is Significantly Reduced in NK Cells after Allogeneic Stem Cell Transplantation in Patients with Severe Graft-versus-Host Disease. Int. J. Mol. Sci. 2016, 17, 1797.

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