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Int. J. Mol. Sci. 2016, 17(11), 1823; doi:10.3390/ijms17111823

Pretransplant Levels of CRP and Interleukin-6 Family Cytokines; Effects on Outcome after Allogeneic Stem Cell Transplantation

1
Section for Hematology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway
2
Department of Clinical Dentistry, University of Bergen, 5020 Bergen, Norway
3
Section for Hematology, Institute of Clinical Science, University of Bergen, 5020 Bergen, Norway
4
Department of Hematology, University of Oslo, 0424 Oslo, Norway
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Muraca
Received: 23 September 2016 / Revised: 22 October 2016 / Accepted: 26 October 2016 / Published: 1 November 2016
(This article belongs to the Special Issue Advances in Cell Transplantation)
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Abstract

Several pretransplant factors, including CRP (C-reactive protein) levels, reflect the risk of complications after allogeneic stem cell transplantation. IL-6 induces CRP increase, and we therefore investigated the effects of pretransplant IL-6, soluble IL-6 receptors, IL-6 family cytokines and CRP serum levels on outcome for 100 consecutive allotransplant recipients. All patients had related donors, none had active infections and 99 patients were in complete remission before conditioning. The incidence of acute graft versus host disease (aGVHD) requiring treatment was 40%, survival at Day +100 82%, and overall survival 48%. Despite a significant correlation between pretransplant CRP and IL-6 levels, only CRP levels significantly influenced transplant-related mortality (TRM). However, CRP did not influence overall survival (OS). Pretransplant IL-31 influenced late TRM. Finally, there was a significant association between pretransplant IL-6 and early postconditioning weight gain (i.e., fluid retention), and this fluid retention was a risk factor for aGVHD, TRM and OS. To conclude, pretransplant CRP, IL-31 and early posttransplant fluid retention were independent risk factors for TRM and survival after allotransplantation. View Full-Text
Keywords: allogeneic stem cell transplantation; interleukin 6; interleukin 31; C reactive protein; graft versus host disease; comorbidity; fluid retention allogeneic stem cell transplantation; interleukin 6; interleukin 31; C reactive protein; graft versus host disease; comorbidity; fluid retention
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MDPI and ACS Style

Tvedt, T.H.; Lie, S.A.; Reikvam, H.; Rye, K.P.; Lindås, R.; Gedde-Dahl, T.; Ahmed, A.B.; Bruserud, Ø. Pretransplant Levels of CRP and Interleukin-6 Family Cytokines; Effects on Outcome after Allogeneic Stem Cell Transplantation. Int. J. Mol. Sci. 2016, 17, 1823.

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