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Int. J. Mol. Sci. 2016, 17(11), 1790; doi:10.3390/ijms17111790

Preparation of Pure and Stable Chitosan Nanofibers by Electrospinning in the Presence of Poly(ethylene oxide)

1
Laboratoire Rhéologie et Procédés (LRP), University of Grenoble Alpes-CNRS, 38000 Grenoble, France
2
Biomaterials Applications, 6 Rue Lesdiguières, 38000 Grenoble, France
*
Author to whom correspondence should be addressed.
Academic Editors: Hitoshi Sashiwa and Shinsuke Ifuku
Received: 22 September 2016 / Revised: 18 October 2016 / Accepted: 19 October 2016 / Published: 26 October 2016
(This article belongs to the Special Issue Chitins 2016)
View Full-Text   |   Download PDF [3876 KB, uploaded 26 October 2016]   |  

Abstract

Electrospinning was employed to obtain chitosan nanofibers from blends of chitosans (CS) and poly(ethylene oxide) (PEO). Blends of chitosan (MW (weight-average molecular weight) = 102 kg/mol) and PEO (M (molecular weight) = 1000 kg/mol) were selected to optimize the electrospinning process parameters. The PEO powder was solubilized into chitosan solution at different weight ratios in 0.5 M acetic acid. The physicochemical changes of the nanofibers were determined by scanning electron microscopy (SEM), swelling capacity, and nuclear magnetic resonance (NMR) spectroscopy. For stabilization, the produced nanofibers were neutralized with K2CO3 in water or 70% ethanol/30% water as solvent. Subsequently, repeated washings with pure water were performed to extract PEO, potassium acetate and carbonate salts formed in the course of chitosan nanofiber purification. The increase of PEO content in the blend from 20 to 40 w% exhibited bead-free fibers with average diameters 85 ± 19 and 147 ± 28 nm, respectively. Their NMR analysis proved that PEO and the salts were nearly completely removed from the nanostructure of chitosan, demonstrating that the adopted strategy is successful for producing pure chitosan nanofibers. In addition, the nanofibers obtained after neutralization in ethanol-aqueous solution has better structural stability, at least for six months in aqueous solutions (phosphate buffer (PBS) or water). View Full-Text
Keywords: electrospinning; chitosan; PEO; nanofiber; stability electrospinning; chitosan; PEO; nanofiber; stability
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mengistu Lemma, S.; Bossard, F.; Rinaudo, M. Preparation of Pure and Stable Chitosan Nanofibers by Electrospinning in the Presence of Poly(ethylene oxide). Int. J. Mol. Sci. 2016, 17, 1790.

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