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Int. J. Mol. Sci. 2016, 17(10), 1762; doi:10.3390/ijms17101762

Screening the Toxicity of Selected Personal Care Products Using Embryo Bioassays: 4-MBC, Propylparaben and Triclocarban

1
CIMAR/CIIMAR, Laboratório Associado—Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade do Porto, Av. General Norton de Matos s/n, 4450-208 Porto, Portugal
2
Escola Superior de Tecnologia de Saúde do Porto, Instituto Politécnico do Porto, 4200-072 Porto, Portugal
3
FCUP-Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Juliette Legler
Received: 9 August 2016 / Revised: 17 September 2016 / Accepted: 10 October 2016 / Published: 21 October 2016
(This article belongs to the Special Issue Zebrafish: A Model for Toxicological Research)
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Abstract

Recently, several emerging pollutants, including Personal Care Products (PCPs), have been detected in aquatic ecosystems, in the ng/L or µg/L range. Available toxicological data is limited, and, for certain PCPs, evidence indicates a potential risk for the environment. Hence, there is an urgent need to gather ecotoxicological data on PCPs as a proxy to improve risk assessment. Here, the toxicity of three different PCPs (4-Methylbenzylidene Camphor (4-MBC), propylparaben and triclocarban) was tested using embryo bioassays with Danio rerio (zebrafish) and Paracentrotus lividus (sea urchin). The No Observed Effect Concentration (NOEC) for triclocarban was 0.256 µg/L for sea urchin and 100 µg/L for zebrafish, whereas NOEC for 4-MBC was 0.32 µg/L for sea urchin and 50 µg/L for zebrafish. Both PCPs impacted embryo development at environmentally relevant concentrations. In comparison with triclocarban and 4-MBC, propylparaben was less toxic for both sea urchin (NOEC = 160 µg/L) and zebrafish (NOEC = 1000 µg/L). Overall, this study further demonstrates the sensitivity of embryo bioassays as a high-throughput approach for testing the toxicity of emerging pollutants. View Full-Text
Keywords: personal care products; sea urchin; zebrafish; embryo bioassays; risk assessment; 4-Methylbenzylidene Camphor; propylparaben; triclocarban; Registration; Evaluation; Authorization; and Restriction of Chemicals (REACH) personal care products; sea urchin; zebrafish; embryo bioassays; risk assessment; 4-Methylbenzylidene Camphor; propylparaben; triclocarban; Registration; Evaluation; Authorization; and Restriction of Chemicals (REACH)
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MDPI and ACS Style

Torres, T.; Cunha, I.; Martins, R.; Santos, M.M. Screening the Toxicity of Selected Personal Care Products Using Embryo Bioassays: 4-MBC, Propylparaben and Triclocarban. Int. J. Mol. Sci. 2016, 17, 1762.

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