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Int. J. Mol. Sci. 2016, 17(10), 1697; doi:10.3390/ijms17101697

Gelation Behaviors and Mechanism of Silk Fibroin According to the Addition of Nitrate Salts

Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University, Daejeon 34134, Korea
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Academic Editors: John G. Hardy and Chris Holland
Received: 10 August 2016 / Revised: 8 September 2016 / Accepted: 28 September 2016 / Published: 10 October 2016
(This article belongs to the Special Issue Silk-Based Materials: From Production to Characterization)
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Abstract

Silk fibroin (SF) is a typical fibrous protein that is secreted by silkworms and spiders. It has been used in a variety of areas, and especially for tissue-engineering scaffolds, due to its sound processability, mechanical properties, biodegradability, and biocompatibility. With respect to gelation, the SF gelation time is long in aqueous solutions, so a novel approach is needed to shorten this time. The solubility of regenerated SF is sound in formic acid (FA), which is a carboxylic acid of the simplest structure. In this study, SF was dissolved in formic acid, and the addition of salts then induced a rapid gelation that accompanied a solution-color change. Based on the gelation behaviors of the SF solution according to different SF and salt concentrations, the gelation mechanism was investigated. View Full-Text
Keywords: silk fibroin; gelation; nitration; tyrosine silk fibroin; gelation; nitration; tyrosine
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MDPI and ACS Style

Im, D.S.; Kim, M.H.; Yoon, Y.I.; Park, W.H. Gelation Behaviors and Mechanism of Silk Fibroin According to the Addition of Nitrate Salts. Int. J. Mol. Sci. 2016, 17, 1697.

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