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Int. J. Mol. Sci. 2016, 17(10), 1675; doi:10.3390/ijms17101675

Genome-Wide Identification, Characterization and Expression Analysis of the Solute Carrier 6 Gene Family in Silkworm (Bombyx mori)

1
State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, China
2
Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing 400016, China
3
Chongqing Engineering and Technology Research Center for Novel Silk Materials, Chongqing 400715, China
*
Author to whom correspondence should be addressed.
Academic Editor: Kun Yan Zhu
Received: 5 August 2016 / Revised: 6 September 2016 / Accepted: 26 September 2016 / Published: 3 October 2016
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

The solute carrier 6 (SLC6) gene family, initially known as the neurotransmitter transporters, plays vital roles in the regulation of neurotransmitter signaling, nutrient absorption and motor behavior. In this study, a total of 16 candidate genes were identified as SLC6 family gene homologs in the silkworm (Bombyx mori) genome. Spatio-temporal expression patterns of silkworm SLC6 gene transcripts indicated that these genes were highly and specifically expressed in midgut, brain and gonads; moreover, these genes were expressed primarily at the feeding stage or adult stage. Levels of expression for most midgut-specific and midgut-enriched gene transcripts were down-regulated after starvation but up-regulated after re-feeding. In addition, we observed that expression levels of these genes except for BmSLC6-15 and BmGT1 were markedly up-regulated by a juvenile hormone analog. Moreover, brain-enriched genes showed differential expression patterns during wandering and mating processes, suggesting that these genes may be involved in modulating wandering and mating behaviors. Our results improve our understanding of the expression patterns and potential physiological functions of the SLC6 gene family, and provide valuable information for the comprehensive functional analysis of the SLC6 gene family. View Full-Text
Keywords: Bombyx mori; expression pattern; motor behavior; nutrient absorption; the solute carrier 6 (SLC6) gene Bombyx mori; expression pattern; motor behavior; nutrient absorption; the solute carrier 6 (SLC6) gene
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Tang, X.; Liu, H.; Chen, Q.; Wang, X.; Xiong, Y.; Zhao, P. Genome-Wide Identification, Characterization and Expression Analysis of the Solute Carrier 6 Gene Family in Silkworm (Bombyx mori). Int. J. Mol. Sci. 2016, 17, 1675.

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