Elevated Expression of Calpain-4 Predicts Poor Prognosis in Patients with Gastric Cancer after Gastrectomy
AbstractCalpain-4 belongs to the calpain family of calcium-dependent cysteine proteases, and functions as a small regulatory subunit of the calpains. Recent evidence indicates that calpain-4 plays critical roles in tumor migration and invasion. However, the roles of calpain-4 in gastric tumorigenesis remain poorly understood. Herein, we examined calpain-4 expression by immunohistochemical staining on tissue microarrays containing tumor samples of 174 gastric cancer patients between 2004 and 2008 at a single center. The Kaplan-Meier method was used to compare survival curves, and expression levels were correlated to clinicopathological factors and overall survival. Our data demonstrated that calpain-4 was generally increased in gastric cancer cell lines and primary tumor tissues. High expression of calpain-4 was positively associated with vessel invasion, lymph node metastasis, and advanced TNM (Tumor Node Metastasis) stage. Multivariate analysis identified calpain-4 as an independent prognostic factor for poor prognosis. A predictive nomogram integrating calpain-4 expression with other independent prognosticators was constructed, which generated a better prognostic value for overall survival of gastric cancer patients than a TNM staging system. In conclusion, calpain-4 could be regarded as a potential prognosis indicator for clinical outcomes in gastric cancer. View Full-Text
Share & Cite This Article
Peng, P.; Min, L.; Song, S.; Zhao, J.; Li, L.; Yang, C.; Shao, M.; Zhang, M.; Wu, H.; Zhang, J.; Li, C.; Wang, X.; Wang, H.; Qin, J.; Ruan, Y.; Gu, J. Elevated Expression of Calpain-4 Predicts Poor Prognosis in Patients with Gastric Cancer after Gastrectomy. Int. J. Mol. Sci. 2016, 17, 1612.
Peng P, Min L, Song S, Zhao J, Li L, Yang C, Shao M, Zhang M, Wu H, Zhang J, Li C, Wang X, Wang H, Qin J, Ruan Y, Gu J. Elevated Expression of Calpain-4 Predicts Poor Prognosis in Patients with Gastric Cancer after Gastrectomy. International Journal of Molecular Sciences. 2016; 17(10):1612.Chicago/Turabian Style
Peng, Peike; Min, Lingqiang; Song, Shushu; Zhao, Junjie; Li, Lili; Yang, Caiting; Shao, Miaomiao; Zhang, Mingming; Wu, Hao; Zhang, Jie; Li, Can; Wang, Xuefei; Wang, Hongshan; Qin, Jing; Ruan, Yuanyuan; Gu, Jianxin. 2016. "Elevated Expression of Calpain-4 Predicts Poor Prognosis in Patients with Gastric Cancer after Gastrectomy." Int. J. Mol. Sci. 17, no. 10: 1612.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.