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Int. J. Mol. Sci. 2016, 17(10), 1612; doi:10.3390/ijms17101612

Elevated Expression of Calpain-4 Predicts Poor Prognosis in Patients with Gastric Cancer after Gastrectomy

1
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
2
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
3
Institute of Biomedical Science, Fudan University, Shanghai 200032, China
*
Authors to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 26 July 2016 / Revised: 14 September 2016 / Accepted: 19 September 2016 / Published: 27 September 2016
(This article belongs to the Collection Advances in Molecular Oncology)
View Full-Text   |   Download PDF [2604 KB, uploaded 27 September 2016]   |  

Abstract

Calpain-4 belongs to the calpain family of calcium-dependent cysteine proteases, and functions as a small regulatory subunit of the calpains. Recent evidence indicates that calpain-4 plays critical roles in tumor migration and invasion. However, the roles of calpain-4 in gastric tumorigenesis remain poorly understood. Herein, we examined calpain-4 expression by immunohistochemical staining on tissue microarrays containing tumor samples of 174 gastric cancer patients between 2004 and 2008 at a single center. The Kaplan-Meier method was used to compare survival curves, and expression levels were correlated to clinicopathological factors and overall survival. Our data demonstrated that calpain-4 was generally increased in gastric cancer cell lines and primary tumor tissues. High expression of calpain-4 was positively associated with vessel invasion, lymph node metastasis, and advanced TNM (Tumor Node Metastasis) stage. Multivariate analysis identified calpain-4 as an independent prognostic factor for poor prognosis. A predictive nomogram integrating calpain-4 expression with other independent prognosticators was constructed, which generated a better prognostic value for overall survival of gastric cancer patients than a TNM staging system. In conclusion, calpain-4 could be regarded as a potential prognosis indicator for clinical outcomes in gastric cancer. View Full-Text
Keywords: gastric cancer; calpain-4; prognosis; biomarker; overall survival; nomogram gastric cancer; calpain-4; prognosis; biomarker; overall survival; nomogram
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Peng, P.; Min, L.; Song, S.; Zhao, J.; Li, L.; Yang, C.; Shao, M.; Zhang, M.; Wu, H.; Zhang, J.; Li, C.; Wang, X.; Wang, H.; Qin, J.; Ruan, Y.; Gu, J. Elevated Expression of Calpain-4 Predicts Poor Prognosis in Patients with Gastric Cancer after Gastrectomy. Int. J. Mol. Sci. 2016, 17, 1612.

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