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Int. J. Mol. Sci. 2016, 17(1), 75; doi:10.3390/ijms17010075

Regulatory System for Stem/Progenitor Cell Niches in the Adult Rodent Pituitary

Organization for the Strategic Coordination of Research and Intellectual Property, Meiji University, Kanagawa 214-8571, Japan
Institute of Reproduction and Endocrinology, Meiji University, Kanagawa 214-8571, Japan
Division of Life Science, Graduate School of Agriculture, Meiji University, Kanagawa 214-8571, Japan
Department of Life Science, School of Agriculture, Meiji University, Kanagawa 214-8571, Japan
Author to whom correspondence should be addressed.
Academic Editor: Wilhelm Bloch
Received: 11 December 2015 / Revised: 27 December 2015 / Accepted: 29 December 2015 / Published: 9 January 2016
(This article belongs to the Special Issue Stem Cell Activation in Adult Organism)
View Full-Text   |   Download PDF [1303 KB, uploaded 9 January 2016]   |  


The anterior lobe of the pituitary gland is a master endocrine tissue composed of five types of endocrine cells. Although the turnover rate of pituitary endocrine cells is as low as about 1.6% per day, recent studies have demonstrated that Sex-determining region Y-box 2 (SOX2)+-cells exist as pituitary stem/progenitor cells in the adult anterior lobe and contribute to cell regeneration. Notably, SOX2+-pituitary stem/progenitor cells form two types of niches in this tissue: the marginal cell layer (MCL-niche) and the dense cell clusters scattering in the parenchyma (parenchymal-niche). However, little is known about the mechanisms and factors for regulating the pituitary stem/progenitor cell niches, as well as the functional differences between the two types of niches. Elucidation of the regulatory mechanisms in the niches might enable us to understand the cell regeneration system that acts in accordance with physiological demands in the adult pituitary. In this review, so as to reveal the regulatory mechanisms of the two types of niche, we summarize the regulatory factors and their roles in the adult rodent pituitary niches by focusing on three components: soluble factors, cell surface proteins and extracellular matrixes. View Full-Text
Keywords: pituitary; stem/progenitor cells; niche; signaling molecules; cell regeneration pituitary; stem/progenitor cells; niche; signaling molecules; cell regeneration

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Yoshida, S.; Kato, T.; Kato, Y. Regulatory System for Stem/Progenitor Cell Niches in the Adult Rodent Pituitary. Int. J. Mol. Sci. 2016, 17, 75.

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