Molecular Evolution of Aralkylamine N-Acetyltransferase in Fish: A Genomic Survey
AbstractAll living organisms synchronize biological functions with environmental changes; melatonin plays a vital role in regulating daily and seasonal variations. Due to rhythmic activity of the timezyme aralkylamine N-acetyltransferase (AANAT), the blood level of melatonin increases at night and decreases during daytime. Whereas other vertebrates have a single form of AANAT, bony fishes possess various isoforms of aanat genes, though the reasons are still unclear. Here, we have taken advantage of multiple unpublished teleost aanat sequences to explore and expand our understanding of the molecular evolution of aanat in fish. Our results confirm that two rounds of whole-genome duplication (WGD) led to the existence of three fish isoforms of aanat, i.e., aanat1a, aanat1b, and aanat2; in addition, gene loss led to the absence of some forms from certain special fish species. Furthermore, we suggest the different roles of two aanat1s in amphibious mudskippers, and speculate that the loss of aanat1a, may be related to terrestrial vision change. Several important sites of AANAT proteins and regulatory elements of aanat genes were analyzed for structural comparison and functional forecasting, respectively, which provides insights into the molecular evolution of the differences between AANAT1 and AANAT2. View Full-Text
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Li, J.; You, X.; Bian, C.; Yu, H.; Coon, S.L.; Shi, Q. Molecular Evolution of Aralkylamine N-Acetyltransferase in Fish: A Genomic Survey. Int. J. Mol. Sci. 2016, 17, 51.
Li J, You X, Bian C, Yu H, Coon SL, Shi Q. Molecular Evolution of Aralkylamine N-Acetyltransferase in Fish: A Genomic Survey. International Journal of Molecular Sciences. 2016; 17(1):51.Chicago/Turabian Style
Li, Jia; You, Xinxin; Bian, Chao; Yu, Hui; Coon, Steven L.; Shi, Qiong. 2016. "Molecular Evolution of Aralkylamine N-Acetyltransferase in Fish: A Genomic Survey." Int. J. Mol. Sci. 17, no. 1: 51.
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