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Int. J. Mol. Sci. 2016, 17(1), 29; doi:10.3390/ijms17010029

Adiponectin Induces Oncostatin M Expression in Osteoblasts through the PI3K/Akt Signaling Pathway

Department of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang 322100, China
School of Pharmacy, China Medical University, Taichung 40402, Taiwan
School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
Department of Orthopedic Surgery, China Medical University Hospital, Taichung 40402, Taiwan
Department of Orthopedics, Dongyang Peoples’ Hospital, Dongyang 322100, China
Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan
Department of Pharmacology, School of Medicine, China Medical University, Taichung 40402, Taiwan
Department of Biotechnology, College of Health Science, Asia University, Taichung 41354, Taiwan
Author to whom correspondence should be addressed.
Academic Editor: Sanjay K. Srivastava
Received: 10 November 2015 / Revised: 16 December 2015 / Accepted: 22 December 2015 / Published: 25 December 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [1243 KB, uploaded 25 December 2015]   |  


Rheumatoid arthritis (RA), a common autoimmune disorder, is associated with a chronic inflammatory response and unbalanced bone metabolism within the articular microenvironment. Adiponectin, an adipokine secreted by adipocytes, is involved in multiple functions, including lipid metabolism and pro-inflammatory activity. However, the mechanism of adiponectin performance within arthritic inflammation remains unclear. In this study, we observed the effect of adiponectin on the expression of oncostatin M (OSM), a pro-inflammatory cytokine, in human osteoblastic cells. Pretreatment of cells with inhibitors of phosphatidylinositol 3-kinase (PI3K), Akt, and nuclear factor (NF)-κB reduced the adiponectin-induced OSM expression in osteoblasts. Stimulation of the cells with adiponectin increased phosphorylation of PI3K, Akt, and p65. Adiponectin treatment of osteoblasts increased OSM-luciferase activity and p65 binding to NF-κB on the OSM promoter. Our results indicate that adiponectin increased OSM expression via the PI3K, Akt, and NF-κB signaling pathways in osteoblastic cells, suggesting that adiponectin is a novel target for arthritis treatment. View Full-Text
Keywords: rheumatoid arthritis; adiponectin; oncostatin M; osteoblasts rheumatoid arthritis; adiponectin; oncostatin M; osteoblasts

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MDPI and ACS Style

Su, C.-M.; Lee, W.-L.; Hsu, C.-J.; Lu, T.-T.; Wang, L.-H.; Xu, G.-H.; Tang, C.-H. Adiponectin Induces Oncostatin M Expression in Osteoblasts through the PI3K/Akt Signaling Pathway. Int. J. Mol. Sci. 2016, 17, 29.

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