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Int. J. Mol. Sci. 2015, 16(9), 22137-22150; doi:10.3390/ijms160922137

MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line

1
Department of Respiratory Diseases, General Hospital of Shenyang Military Command, Shenyang 110016, China
2
Department of Pharmacy, General Hospital of Shenyang Military Command, Shenyang 110016, China
3
Department of Pharmacy, Beijing Chuiyangliu Hospital Affiliated to Tsinghua University, Beijing 100022, China
4
Institute of Toxicology and Pharmacology, Medicine Military Medical Science Academy of the Chinese PLA, Beijing 100850, China
5
Institute of Radiation, Medicine Military Medical Science Academy of the Chinese PLA, Beijing 100850, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Received: 6 July 2015 / Revised: 27 August 2015 / Accepted: 27 August 2015 / Published: 14 September 2015
(This article belongs to the Special Issue MicroRNA Regulation)
View Full-Text   |   Download PDF [3217 KB, uploaded 14 September 2015]   |  

Abstract

MiR-122 is a novel tumor suppresser and its expression induces cell cycle arrest, or apoptosis, and inhibits cell proliferation in multiple cancer cells, including non-small cell lung cancer (NSCLC) cells. Radioresistance of cancer cell leads to the major drawback of radiotherapy for NSCLC and the induction of radiosensitization could be a useful strategy to fix this problem. The present work investigates the function of miR-122 in inducing radiosensitization in A549 cell, a type of NSCLC cells. MiR-122 induces the radiosensitization of A549 cells. MiR-122 also boosts the inhibitory activity of ionizing radiation (IR) on cancer cell anchor-independent growth and invasion. Moreover, miR-122 reduced the expression of its targeted genes related to tumor-survival or cellular stress response. These results indicate that miR-122 would be a novel strategy for NSCLC radiation-therapy. View Full-Text
Keywords: non-small cell lung cancer; microrna122; adenoviral vector; ionizing radiation; radiosensitization non-small cell lung cancer; microrna122; adenoviral vector; ionizing radiation; radiosensitization
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ma, D.; Jia, H.; Qin, M.; Dai, W.; Wang, T.; Liang, E.; Dong, G.; Wang, Z.; Zhang, Z.; Feng, F. MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line. Int. J. Mol. Sci. 2015, 16, 22137-22150.

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