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Int. J. Mol. Sci. 2015, 16(9), 20277-20289; doi:10.3390/ijms160920277

The Effect of Cationic Polyamidoamine Dendrimers on Physicochemical Characteristics of Hydrogels with Erythromycin

Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, Poland
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Author to whom correspondence should be addressed.
Academic Editor: Már Másson
Received: 3 July 2015 / Revised: 6 August 2015 / Accepted: 7 August 2015 / Published: 27 August 2015
(This article belongs to the Special Issue Drug Delivery and Antimicrobial Agents)
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Abstract

Polyamidoamine dendrimers (PAMAM) represent a new class of hyperbranched, monodisperse, three-dimensional polymers with unique properties, which make them very promising carriers of antimicrobial agents. The present study aimed to evaluate the influence of PAMAM-NH2 dendrimers generation two (G2) or three (G3) on physicochemical characteristics and structure of hydrogels with a model antibacterial lipophilic drug—erythromycin—commonly used in topical applications. From the obtained rheograms, it can be concluded that tested hydrogels were non-Newtonian thixotropic systems with shear-thinning behaviour. The dissolution tests revealed that erythromycin was definitely faster released from formulations containing PAMAM-NH2 in concentration and generation dependent manner. However, the addition of PAMAM-NH2 to hydrogels evoked only slight improvement of their antibacterial activity. It was also shown that the structure of hydrogels changed in the presence of PAMAM-NH2 becoming less compact, diversified and more porous. Designed hydrogels with PAMAM-NH2 G2 or G3 were stable stored up to three months at 40 ± 2 °C and 75% ± 5% RH. View Full-Text
Keywords: PAMAM dendrimer; erythromycin; hydrogel; mechanical properties; rheological properties PAMAM dendrimer; erythromycin; hydrogel; mechanical properties; rheological properties
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wróblewska, M.; Winnicka, K. The Effect of Cationic Polyamidoamine Dendrimers on Physicochemical Characteristics of Hydrogels with Erythromycin. Int. J. Mol. Sci. 2015, 16, 20277-20289.

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