Exploiting Size-Dependent Drag and Magnetic Forces for Size-Specific Separation of Magnetic Nanoparticles
AbstractRealizing the full potential of magnetic nanoparticles (MNPs) in nanomedicinerequires the optimization of their physical and chemical properties. Elucidation of the effectsof these properties on clinical diagnostic or therapeutic properties, however, requires thesynthesis or purification of homogenous samples, which has proved to be difficult. Whileinitial simulations indicated that size-selective separation could be achieved by flowingmagnetic nanoparticles through a magnetic field, subsequent in vitro experiments wereunable to reproduce the predicted results. Magnetic field-flow fractionation, however, wasfound to be an effective method for the separation of polydisperse suspensions of iron oxidenanoparticles with diameters greater than 20 nm. While similar methods have been used toseparate magnetic nanoparticles before, no previous work has been done with magneticnanoparticles between 20 and 200 nm. Both transmission electron microscopy (TEM) anddynamic light scattering (DLS) analysis were used to confirm the size of the MNPs. Furtherdevelopment of this work could lead to MNPs with the narrow size distributions necessary fortheir in vitro and in vivo optimization. View Full-Text
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Rogers, H.B.; Anani, T.; Choi, Y.S.; Beyers, R.J.; David, A.E. Exploiting Size-Dependent Drag and Magnetic Forces for Size-Specific Separation of Magnetic Nanoparticles. Int. J. Mol. Sci. 2015, 16, 20001-20019.
Rogers HB, Anani T, Choi YS, Beyers RJ, David AE. Exploiting Size-Dependent Drag and Magnetic Forces for Size-Specific Separation of Magnetic Nanoparticles. International Journal of Molecular Sciences. 2015; 16(8):20001-20019.Chicago/Turabian Style
Rogers, Hunter B.; Anani, Tareq; Choi, Young S.; Beyers, Ronald J.; David, Allan E. 2015. "Exploiting Size-Dependent Drag and Magnetic Forces for Size-Specific Separation of Magnetic Nanoparticles." Int. J. Mol. Sci. 16, no. 8: 20001-20019.