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Int. J. Mol. Sci. 2015, 16(8), 20001-20019; doi:10.3390/ijms160820001

Exploiting Size-Dependent Drag and Magnetic Forces for Size-Specific Separation of Magnetic Nanoparticles

1
Department of Chemical Engineering, Auburn University, 212 Ross Hall, Auburn, AL 36849, USA
2
Auburn University MRI Research Center, Auburn, AL 36849, USA
*
Author to whom correspondence should be addressed.
Academic Editor: O. Thompson Mefford
Received: 30 June 2015 / Revised: 3 August 2015 / Accepted: 10 August 2015 / Published: 21 August 2015
(This article belongs to the Special Issue Magnetic Nanoparticles 2015)
View Full-Text   |   Download PDF [2938 KB, uploaded 21 August 2015]   |  

Abstract

Realizing the full potential of magnetic nanoparticles (MNPs) in nanomedicinerequires the optimization of their physical and chemical properties. Elucidation of the effectsof these properties on clinical diagnostic or therapeutic properties, however, requires thesynthesis or purification of homogenous samples, which has proved to be difficult. Whileinitial simulations indicated that size-selective separation could be achieved by flowingmagnetic nanoparticles through a magnetic field, subsequent in vitro experiments wereunable to reproduce the predicted results. Magnetic field-flow fractionation, however, wasfound to be an effective method for the separation of polydisperse suspensions of iron oxidenanoparticles with diameters greater than 20 nm. While similar methods have been used toseparate magnetic nanoparticles before, no previous work has been done with magneticnanoparticles between 20 and 200 nm. Both transmission electron microscopy (TEM) anddynamic light scattering (DLS) analysis were used to confirm the size of the MNPs. Furtherdevelopment of this work could lead to MNPs with the narrow size distributions necessary fortheir in vitro and in vivo optimization. View Full-Text
Keywords: field-flow fractionation; iron oxide nanoparticles; size separation; magneticnanoparticles; nanomedicine field-flow fractionation; iron oxide nanoparticles; size separation; magneticnanoparticles; nanomedicine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rogers, H.B.; Anani, T.; Choi, Y.S.; Beyers, R.J.; David, A.E. Exploiting Size-Dependent Drag and Magnetic Forces for Size-Specific Separation of Magnetic Nanoparticles. Int. J. Mol. Sci. 2015, 16, 20001-20019.

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