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Int. J. Mol. Sci. 2015, 16(8), 19645-19656; doi:10.3390/ijms160819645

Engineering of Self-Assembled Fibronectin Matrix Protein and Its Effects on Mesenchymal Stem Cells

1
Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Korea
2
Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Korea
3
Department of Biochemistry, Inha University School of Medicine, Incheon 400-712, Korea
4
Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 330-714, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Qiang “Shawn” Chen
Received: 15 June 2015 / Revised: 30 July 2015 / Accepted: 12 August 2015 / Published: 19 August 2015
(This article belongs to the Special Issue Protein Engineering)
View Full-Text   |   Download PDF [1050 KB, uploaded 19 August 2015]   |  

Abstract

Fibronectin (FN) contributes to cell adhesion, proliferation, and differentiation in various cell types. To enhance the activity of fibronectin at the sites of focal adhesion, we engineered a novel recombinant fibronectin (FNIII10) fragment connected to the peptide amphiphile sequence (PA), LLLLLLCCCGGDS. In this study, the effects of FNIII10-PA on rat mesenchymal stem cells (rMSCs) were compared with those of FNIII10. FNIII10-PA showed the prominent protein adhesion activity. In addition, FNIII10-PA showed a significantly higher effect on adhesion, proliferation, and differentiation of rMSCs than FNIII10. Taken together, the FNIII10-containing self-assembled sequence enhanced rMSCs adhesion, proliferation, and differentiation. View Full-Text
Keywords: fibronectin; peptide amphiphile; rat mesenchymal stem cells; cellular activity fibronectin; peptide amphiphile; rat mesenchymal stem cells; cellular activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yun, Y.-R.; Pham, L.B.H.; Yoo, Y.-R.; Lee, S.; Kim, H.-W.; Jang, J.-H. Engineering of Self-Assembled Fibronectin Matrix Protein and Its Effects on Mesenchymal Stem Cells. Int. J. Mol. Sci. 2015, 16, 19645-19656.

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