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Int. J. Mol. Sci. 2015, 16(8), 18454-18473; doi:10.3390/ijms160818454

Novel Electrocardiographic Patterns for the Prediction of Hypertensive Disorders of Pregnancy—From Pathophysiology to Practical Implications

1
Division of Cardiology and Cardiovascular Pathophysiology, Hospital "S.M. della Misericordia", Perugia 06100, Italy
2
Department of Obstetrics and Gynecology, Hospital "San Giovanni Battista", Foligno 06034, Italy
3
Department of Internal medicine, Hospital of Assisi, Assisi 06081, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Philip Newton Baker
Received: 26 April 2015 / Revised: 21 July 2015 / Accepted: 31 July 2015 / Published: 7 August 2015
(This article belongs to the Special Issue Prediction, Diagnostics and Prevention of Pregnancy Complications)
View Full-Text   |   Download PDF [450 KB, uploaded 7 August 2015]   |  

Abstract

Hypertensive disorders of pregnancy are a major cause of poor outcome, including placental abruption, organ failure, cerebrovascular accident and disseminated intravascular coagulation. These disorders are associated with increased fetal risk of intrauterine growth restriction, intrauterine death and prematurity. Electrocardiography (ECG) recently emerged as a useful tool to evaluate cardiovascular complications during pregnancy. Specifically, left atrial abnormalities detected by standard ECG are associated with a fourfold increased risk of developing hypertensive disorders during pregnancy. The mechanisms linking left atrial abnormality on ECG with hypertensive disorders are still elusive. Several mechanisms, possibly reflected by abnormal left atrial activation on ECG, has been suggested. These include increased reactivity to angiotensin II and up-regulation of angiotensin type 1 receptors, with activation of autoantibodies targeting these receptors. View Full-Text
Keywords: pregnancy; pregnancy; high-risk; eclampsia; pre-eclampsia; blood pressure; hypertension; pregnancy-induced; electrocardiography pregnancy; pregnancy; high-risk; eclampsia; pre-eclampsia; blood pressure; hypertension; pregnancy-induced; electrocardiography
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Angeli, F.; Angeli, E.; Verdecchia, P. Novel Electrocardiographic Patterns for the Prediction of Hypertensive Disorders of Pregnancy—From Pathophysiology to Practical Implications. Int. J. Mol. Sci. 2015, 16, 18454-18473.

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