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Int. J. Mol. Sci. 2015, 16(8), 17952-17974; doi:10.3390/ijms160817952

Combined Screening for Early Detection of Pre-Eclampsia

Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul 135-081, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Philip Newton Baker
Received: 30 April 2015 / Revised: 21 July 2015 / Accepted: 22 July 2015 / Published: 4 August 2015
(This article belongs to the Special Issue Prediction, Diagnostics and Prevention of Pregnancy Complications)
View Full-Text   |   Download PDF [705 KB, uploaded 4 August 2015]

Abstract

Although the precise pathophysiology of pre-eclampsia remains unknown, this condition continues to be a major cause of maternal and fetal mortality. Early prediction of pre-eclampsia would allow for timely initiation of preventive therapy. A combination of biophysical and biochemical markers are superior to other tests for early prediction of the development of pre-eclampsia. Apart from the use of parameters in first-trimester aneuploidy screening, cell-free fetal DNA quantification is emerging as a promising marker for prediction of pre-eclampsia. This article reviews the current research of the most important strategies for prediction of pre-eclampsia, including the use of maternal risk factors, mean maternal arterial pressure, ultrasound parameters, and biomarkers. View Full-Text
Keywords: pre-eclampsia; early prediction; maternal risk factors; mean maternal arterial pressure; ultrasound parameters; biomarker; pregnancy-associated plasma protein-A (PAPP-A); cell-free fetal DNA pre-eclampsia; early prediction; maternal risk factors; mean maternal arterial pressure; ultrasound parameters; biomarker; pregnancy-associated plasma protein-A (PAPP-A); cell-free fetal DNA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Park, H.J.; Shim, S.S.; Cha, D.H. Combined Screening for Early Detection of Pre-Eclampsia. Int. J. Mol. Sci. 2015, 16, 17952-17974.

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