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Int. J. Mol. Sci. 2015, 16(8), 19009-19026; doi:10.3390/ijms160819009

Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration

1
Fetal Medicine Unit-Maternal and Child Health and Development Network (SAMID), Department of Obstetrics and Gynaecology, Hospital Universitario "12 de Octubre", Universidad Complutense de Madrid, 28041 Madrid, Spain
2
Department of Clinical Biochemistry, Hospital Universitario "12 de Octubre", Universidad Complutense de Madrid, 28041 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Philip Newton Baker
Received: 30 June 2015 / Revised: 27 July 2015 / Accepted: 3 August 2015 / Published: 13 August 2015
(This article belongs to the Special Issue Prediction, Diagnostics and Prevention of Pregnancy Complications)
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Abstract

Placental dysfunction is involved in a group of obstetrical conditions including preeclampsia, intrauterine growth restriction, and placental abruption. Their timely and accurate recognition is often a challenge since diagnostic criteria are still based on nonspecific signs and symptoms. The discovering of the role of angiogenic-related factors (sFlt-1/PlGF) in the underlying pathophysiology of placental dysfunction, taking into account that angiogenesis-related biomarkers are not specific to any particular placental insufficiency-related disease, has marked an important step for improving their early diagnosis and prognosis assessment. However, sFlt-1/PlGF has not been yet established as a part of most guidelines. We will review the current evidence on the clinical utility of sFlt-1/PlGF and propose a new protocol for its clinical integration. View Full-Text
Keywords: placental insufficiency; preeclampsia; intrauterine growth restriction; placental abruption; angiogenesis; sFlt-1; PlGF placental insufficiency; preeclampsia; intrauterine growth restriction; placental abruption; angiogenesis; sFlt-1; PlGF
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Herraiz, I.; Simón, E.; Gómez-Arriaga, P.I.; Martínez-Moratalla, J.M.; García-Burguillo, A.; Jiménez, E.A.L.; Galindo, A. Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration. Int. J. Mol. Sci. 2015, 16, 19009-19026.

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