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Int. J. Mol. Sci. 2015, 16(8), 18368-18383; doi:10.3390/ijms160818368

The Essential Role of Vitellogenin Receptor in Ovary Development and Vitellogenin Uptake in Bactrocera dorsalis (Hendel)

1
Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing 400715, China
2
Citrus Research Institute, Southwest University, Chongqing 400712, China
3
College of Biology and Environmental Engineering, Guiyang University, Guiyang 550005, China
*
Author to whom correspondence should be addressed.
Academic Editor: Lee A. Bulla
Received: 29 June 2015 / Revised: 24 July 2015 / Accepted: 30 July 2015 / Published: 7 August 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

The vitellogenin receptor (VgR) functions as an essential component in uptaking and transporting vitellogenin (Vg) in female adults, which is involved in ovary development and oviposition. This study aimed to clarify the molecular characteristics and function of VgR in the oriental fruit fly Bactrocera dorsalis (Hendel). Here, we identified the full-length of BdVgR (GenBank Accession No. JX469118), encoding a 1925 residue (aa) protein with a 214.72 kDa molecular mass and several typical motifs of low-density lipoprotein receptor superfamily (LDLR). Phylogenic analysis suggested that BdVgR was evolutionary conserved with other Dipteran VgRs. The expression of BdVgR was exclusively detected in the ovaries rather than head, thorax or other tissues. The developmental expression patterns showed that the signal of BdVgR was detectable in very beginning of adult stage, and positively correlated with the growth rate of ovaries and the expression levels of its ligands. In addition, we also demonstrated that the expression level of BdVgR, and ovary development were significantly suppressed after being injected with BdVgR-targeted dsRNA. Together, all of these results indicated that BdVgR was critical for yolk protein absorption and ovary maturation in B. dorsalis, playing a vital role in female reproduction. View Full-Text
Keywords: Bactrocera dorsalis; vitellogenin receptor; yolk protein; ovary; RNA interference Bactrocera dorsalis; vitellogenin receptor; yolk protein; ovary; RNA interference
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MDPI and ACS Style

Cong, L.; Yang, W.-J.; Jiang, X.-Z.; Niu, J.-Z.; Shen, G.-M.; Ran, C.; Wang, J.-J. The Essential Role of Vitellogenin Receptor in Ovary Development and Vitellogenin Uptake in Bactrocera dorsalis (Hendel). Int. J. Mol. Sci. 2015, 16, 18368-18383.

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