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Int. J. Mol. Sci. 2015, 16(8), 18348-18367; doi:10.3390/ijms160818348

Overview of Nrf2 as Therapeutic Target in Epilepsy

1
Laboratory of Neurochemistry (Neurosciences), National Institute of Pediatrics, D.F. 04530, Mexico
2
Laboratory of Neuroplasticity and Neurodegeneration, Cinvestav, D.F. 07360, Mexico
3
Laboratory of Physiology of the Reticular Formation, National Institute of Neurology and Neurosurgery-MVS, D.F. 14269, Mexico
4
Laboratory of Pharmacology, National Institute of Pediatrics, D.F. 04530, Mexico
5
Service of Endocrinology, National Institute of Pediatrics, D.F. 04530, Mexico
6
Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, D.F. 04150, Mexico
7
Department of Comparative Biology, Faculty of Sciences, National Autonomous University of Mexico, D.F. 04150, Mexico
*
Authors to whom correspondence should be addressed.
Academic Editor: Kenji Hashimoto
Received: 16 June 2015 / Revised: 15 July 2015 / Accepted: 23 July 2015 / Published: 7 August 2015
View Full-Text   |   Download PDF [1359 KB, uploaded 7 August 2015]   |  

Abstract

Oxidative stress is a biochemical state of imbalance in the production of reactive oxygen and nitrogen species and antioxidant defenses. It is involved in the physiopathology of degenerative and chronic neuronal disorders, such as epilepsy. Experimental evidence in humans and animals support the involvement of oxidative stress before and after seizures. In the past few years, research has increasingly focused on the molecular pathways of this process, such as that involving transcription factor nuclear factor E2-related factor 2 (Nrf2), which plays a central role in the regulation of antioxidant response elements (ARE) and modulates cellular redox status. The aim of this review is to present experimental evidence on the role of Nrf2 in this neurological disorder and to further determine the therapeutic impact of Nrf2 in epilepsy. View Full-Text
Keywords: Nrf2; stress oxidative; transcription factor nuclear; epilepsy Nrf2; stress oxidative; transcription factor nuclear; epilepsy
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Carmona-Aparicio, L.; Pérez-Cruz, C.; Zavala-Tecuapetla, C.; Granados-Rojas, L.; Rivera-Espinosa, L.; Montesinos-Correa, H.; Hernández-Damián, J.; Pedraza-Chaverri, J.; Sampieri, A.I.; Coballase-Urrutia, E.; Cárdenas-Rodríguez, N. Overview of Nrf2 as Therapeutic Target in Epilepsy. Int. J. Mol. Sci. 2015, 16, 18348-18367.

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