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Int. J. Mol. Sci. 2015, 16(8), 17870-17884; doi:10.3390/ijms160817870

A Pilot Study of the Photoprotective Effects of Strawberry-Based Cosmetic Formulations on Human Dermal Fibroblasts

Department of Clinical Sciences, Faculty of Medicine, Polytechnic University of Marche, Ancona 60131, Italy
Area de Nutrición y Salud, Universidad Internacional Iberoamericana (UNINI), Campeche 24040, Mexico
Facultad de Ciencias de la Salud, Universidad Nacional de Chimborazo, Riobamba 060150, Ecuador
Grupo de Investigación en Polifenoles (GIP-USAL), Faculty of Pharmacy, Salamanca University, Campus Miguel de Unamuno, Salamanca E37007, Spain
Dipartimento di Scienze Biomediche e Sanità Pubblica, Facoltà di Medicina, Università Politecnica delle Marche Via Ranieri 65, Ancona 60131, Italy
Department of Physiology, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Centre, University of Granada, Granada 18071, Spain
Dipartimento di Scienze Agrarie, Alimentari e Ambientali, Università Politecnica delle Marche, Ancona 60131, Italy
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 15 June 2015 / Revised: 24 July 2015 / Accepted: 28 July 2015 / Published: 4 August 2015
View Full-Text   |   Download PDF [1613 KB, uploaded 4 August 2015]   |  


Strawberry polyphenols have been extensively studied over the last two decades for their beneficial properties. Recently, their possible use in ameliorating skin conditions has also been proposed; however, their role in preventing UVA-induced damage in cosmetic formulation has not yet been investigated. Skin is constantly exposed to several environmental stressors, such as UVA radiation, that induce oxidative stress, inflammation and cell death via the production of reactive oxygen species (ROS). In the present study, we assessed the potential photoprotective capacity of different strawberry-based formulations, enriched with nanoparticles of Coenzyme Q10 and with sun protection factor 10 (SPF10), in human dermal fibroblasts (HuDe) exposed to UVA radiation. We confirmed that strawberries are a very rich source of polyphenols, anthocyanins and vitamins, and possess high total antioxidant capacity. We also showed that strawberry extracts (25 μg/mL–1 mg/mL) exert a noticeable photoprotection in HuDe, increasing cell viability in a dose-dependent way, and that these effects are potentiated by the presence of CoQ10red (100 μg/mL). We have demonstrated for the first time that the topical use of strawberry extract may provide good photoprotection, even if more in-depth studies are strongly encouraged in order to evaluate the cellular and molecular effects of strawberry protection. View Full-Text
Keywords: strawberry polyphenols; skin damage; UVA-radiation; topical formulation; cell viability; human dermal fibroblasts strawberry polyphenols; skin damage; UVA-radiation; topical formulation; cell viability; human dermal fibroblasts

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gasparrini, M.; Forbes-Hernandez, T.Y.; Afrin, S.; Alvarez-Suarez, J.M.; Gonzàlez-Paramàs, A.M.; Santos-Buelga, C.; Bompadre, S.; Quiles, J.L.; Mezzetti, B.; Giampieri, F. A Pilot Study of the Photoprotective Effects of Strawberry-Based Cosmetic Formulations on Human Dermal Fibroblasts. Int. J. Mol. Sci. 2015, 16, 17870-17884.

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