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Int. J. Mol. Sci. 2015, 16(8), 17565-17588; doi:10.3390/ijms160817565

Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis?

1
Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081 Ulm, Germany
2
Institute of Neuropathology, University Hospital Göttingen, Robert-Koch-Str 40, 37075 Göttingen, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Christoph Kleinschnitz
Received: 16 June 2015 / Revised: 20 July 2015 / Accepted: 23 July 2015 / Published: 31 July 2015
(This article belongs to the Special Issue Advances in Multiple Sclerosis)
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Abstract

Many neurodegenerative disorders share a common pathophysiological pathway involving axonal degeneration despite different etiological triggers. Analysis of cytoskeletal markers such as neurofilaments, protein tau and tubulin in cerebrospinal fluid (CSF) may be a useful approach to detect the process of axonal damage and its severity during disease course. In this article, we review the published literature regarding brain-specific CSF markers for cytoskeletal damage in primary progressive multiple sclerosis and amyotrophic lateral sclerosis in order to evaluate their utility as a biomarker for disease progression in conjunction with imaging and histological markers which might also be useful in other neurodegenerative diseases associated with affection of the upper motor neurons. A long-term benefit of such an approach could be facilitating early diagnostic and prognostic tools and assessment of treatment efficacy of disease modifying drugs. View Full-Text
Keywords: primary progressive multiple sclerosis (PPMS); amyotrophic lateral sclerosis (ALS); neurofilaments; biomarker; tau; tubulin primary progressive multiple sclerosis (PPMS); amyotrophic lateral sclerosis (ALS); neurofilaments; biomarker; tau; tubulin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Abdelhak, A.; Junker, A.; Brettschneider, J.; Kassubek, J.; Ludolph, A.C.; Otto, M.; Tumani, H. Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis? Int. J. Mol. Sci. 2015, 16, 17565-17588.

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