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Int. J. Mol. Sci. 2015, 16(8), 17181-17192; doi:10.3390/ijms160817181

Prognostic Value of Preoperative Serum Levels of Periostin (PN) in Early Breast Cancer (BCa)

1
Academic Unit of Medical Oncology, IRCCS San Martino University Hospital—IST National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
2
Department of Medicine, School of Medicine, University of Genoa, Largo Rosanna Benzi 10, 16132 Genoa, Italy
3
Department of Laboratory Medicine, IRCCS San Martino University Hospital—IST National Cancer Research Institute Largo Rosanna Benzi 10, 16132 Genoa, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 17 June 2015 / Revised: 14 July 2015 / Accepted: 17 July 2015 / Published: 28 July 2015
(This article belongs to the Special Issue Molecular Classification of Human Cancer: Diagnosis and Treatment)
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Abstract

PN is a secreted cell adhesion protein critical for carcinogenesis. Elevated serum levels of PN have been implicated as playing an important role in different types of cancer, and a few reports suggest a potential role as a prognostic marker. We evaluated the prognostic significance of preoperative serum PN concentration in patients with BCa receiving curative surgery. Enzyme-Linked Immunosorbent Assay (ELISA) was performed to determine the preoperative serum PN level in 182 patients. The correlations between serum PN concentration with clinical pathological features and PN expression in primary tumor samples were analyzed. The prognostic impact of serum PN levels with all-cause and BCa-specific mortality was also investigated. Appropriate statistics were used. Elevated serum PN levels were significantly associated with patient age (p = 0.005), adjuvant systemic therapy (p = 0.04) and progesterone receptor (PgR) status (p = 0.02). No correlation between PN preoperative serum levels and other clinical-pathological parameters, including either the epithelial or the stromal PN expression of primary tumor or the combination of the two, was found. Similarly, no association between serum PN levels and either all-cause or BCa-specific mortality was found. However, subgroup analysis revealed a correlation between higher PN serum levels and all-cause mortality in patients with node-negative disease (p = 0.05) and in those with a low PgR expression (p = 0.03). Higher levels of serum PN were also found to correlate with BCa-specific mortality in the subgroup of patients who did not receive any adjuvant systemic therapy (p = 0.04). Our findings suggest that PN was detectable in the serum of early BCa patients before surgery and increased base-line serum levels predicted worse long-term survival outcomes in specific subgroups of patients. View Full-Text
Keywords: periostin protein; breast neoplasms; extracellular matrix proteins; prognosis; biomarkers; enzyme-linked immunosorbent assay periostin protein; breast neoplasms; extracellular matrix proteins; prognosis; biomarkers; enzyme-linked immunosorbent assay
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nuzzo, P.V.; Rubagotti, A.; Argellati, F.; Di Meglio, A.; Zanardi, E.; Zinoli, L.; Comite, P.; Mussap, M.; Boccardo, F. Prognostic Value of Preoperative Serum Levels of Periostin (PN) in Early Breast Cancer (BCa). Int. J. Mol. Sci. 2015, 16, 17181-17192.

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