Next Article in Journal
Eosinophil-Derived Neurotoxin (EDN/RNase 2) and the Mouse Eosinophil-Associated RNases (mEars): Expanding Roles in Promoting Host Defense
Previous Article in Journal
Structural and Dynamical Insight into PPARγ Antagonism: In Silico Study of the Ligand-Receptor Interactions of Non-Covalent Antagonists
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2015, 16(7), 15425-15441; doi:10.3390/ijms160715425

The Effect of Electroporation of a Lyotroic Liquid Crystal Genistein-Based Formulation in the Recovery of Murine Melanoma Lesions

1
Department of Pharmacognosy, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania
2
Department of Pharmaceutical Technology, University of Szeged, Szeged 6720, Hungary
3
Dr. Derm Clinic of Anti-Aging Dermatology, Aesthetic Laser and Plastic Surgery, Budapest 1026, Hungary
4
Department of Dermatology and Allergology, University of Szeged, Szeged 6720, Hungary
5
Department of Pathology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
6
Department of Anatomy, Physiology and Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania
7
Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania
8
Department of Obstetrics and Gynecology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania
9
Department of Rehabilitation, Physical Medicine and Rheumatology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania
10
Department of Pharmacognosy, Western University "Vasile Goldis", 310025 Arad, Romania
*
Authors to whom correspondence should be addressed.
Academic Editor: Andrzej Slominski
Received: 5 March 2015 / Revised: 11 June 2015 / Accepted: 25 June 2015 / Published: 8 July 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [2059 KB, uploaded 8 July 2015]   |  

Abstract

A lamellar lyotropic liquid crystal genistein-based formulation (LLC-Gen) was prepared in order to increase the aqueous solubility of the lipophilic phytocompound genistein. The formulation was applied locally, in a murine model of melanoma, with or without electroporation. The results demonstrated that, when the formulation was applied by electroporation, the tumors appeared later. During the 21 days of the experiment, the LLC-Gen formulation decreased the tumor volume, the amount of melanin and the degree of erythema, but when electroporation was applied, all these parameters indicated a better prognosis even (lower tumor volume, amount of melanin and degree of erythema). Although hematoxylin–eosin (HE) staining confirmed the above events, application of the LLC-Gen formulation by electroporation did not lead to a significant effect in terms of the serum concentrations of the protein S100B and serum neuron specific enolase (NSE), or the tissue expression of the platelet-derived growth factor receptor β (PDGFRβ) antibody. View Full-Text
Keywords: genistein; lyotropic liquid crystals; electroporation; murine melanoma genistein; lyotropic liquid crystals; electroporation; murine melanoma
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Danciu, C.; Berkó, S.; Varju, G.; Balázs, B.; Kemény, L.; Németh, I.B.; Cioca, A.; Petruș, A.; Dehelean, C.; Cosmin, C.I.; Amaricai, E.; Toma, C.C. The Effect of Electroporation of a Lyotroic Liquid Crystal Genistein-Based Formulation in the Recovery of Murine Melanoma Lesions. Int. J. Mol. Sci. 2015, 16, 15425-15441.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top