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Int. J. Mol. Sci. 2015, 16(7), 14554-14570; doi:10.3390/ijms160714554

Advances in the in Vivo Raman Spectroscopy of Malignant Skin Tumors Using Portable Instrumentation

1
Department of Medical Physics, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece
2
Department of Skin and Venereal Diseases, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 11 June 2015 / Revised: 20 June 2015 / Accepted: 24 June 2015 / Published: 26 June 2015
(This article belongs to the Special Issue Molecular Classification of Human Cancer: Diagnosis and Treatment)
View Full-Text   |   Download PDF [1455 KB, uploaded 26 June 2015]   |  

Abstract

Raman spectroscopy has emerged as a promising tool for real-time clinical diagnosis of malignant skin tumors offering a number of potential advantages: it is non-intrusive, it requires no sample preparation, and it features high chemical specificity with minimal water interference. However, in vivo tissue evaluation and accurate histopathological classification remain a challenging task for the successful transition from laboratory prototypes to clinical devices. In the literature, there are numerous reports on the applications of Raman spectroscopy to biomedical research and cancer diagnostics. Nevertheless, cases where real-time, portable instrumentations have been employed for the in vivo evaluation of skin lesions are scarce, despite their advantages in use as medical devices in the clinical setting. This paper reviews the advances in real-time Raman spectroscopy for the in vivo characterization of common skin lesions. The translational momentum of Raman spectroscopy towards the clinical practice is revealed by (i) assembling the technical specifications of portable systems and (ii) analyzing the spectral characteristics of in vivo measurements. View Full-Text
Keywords: Raman spectroscopy; in vivo spectroscopy; skin cancer Raman spectroscopy; in vivo spectroscopy; skin cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kourkoumelis, N.; Balatsoukas, I.; Moulia, V.; Elka, A.; Gaitanis, G.; Bassukas, I.D. Advances in the in Vivo Raman Spectroscopy of Malignant Skin Tumors Using Portable Instrumentation. Int. J. Mol. Sci. 2015, 16, 14554-14570.

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