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Int. J. Mol. Sci. 2015, 16(7), 14338-14352; doi:10.3390/ijms160714338

Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity

1
Department of Epidemiology and Biostatistics, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China
2
Fangshan District Center for Disease Control and Prevention, Beijing 102401, China
*
Author to whom correspondence should be addressed.
Academic Editor: Ritva Tikkanen
Received: 27 April 2015 / Revised: 19 June 2015 / Accepted: 19 June 2015 / Published: 24 June 2015
(This article belongs to the Special Issue Gene-Nutrient Interactions)
View Full-Text   |   Download PDF [708 KB, uploaded 24 June 2015]

Abstract

Soybean is a common food for the Chinese people. We aimed to investigate the risk for brachial ankle pulse wave velocity (baPWV) with inflammatory-related SNPs and soybean. baPWV was measured, and 16 inflammatory-related SNPs located on ADIPOQ, CDH13, SIRT3, SIRT6, CXCL12, CXCR4, NOS1, PON1 and CDKN2B were genotyped in 1749 Chinese participants recruited from various communities. ADIPOQ rs12495941 (GT/TT vs. GG: crude OR = 1.27, p = 0.044) and SIRT6 rs107251 (CT/TT vs. CC: crude OR = 0.74, p = 0.009) were associated with abnormal baPWV (baPWV ≥ 1700 cm/s). After adjustment for conventional environmental risk factors, rs12495941 was associated with abnormal baPWV (GT/TT vs. GG: adjusted OR = 1.43, p = 0.011), but the association between rs107251 and abnormal baPWV was not significant (CT/TT vs. CC: adjusted OR = 0.83, p = 0.173). The interaction between rs107251 and soybean intake for different levels of baPWV was statistically significant (p = 0.017). Compared with a high level of soybean intake, a low level of soybean intake can significantly decrease the risk of abnormal baPWV in individuals of rs107251 CT/TT genotypes (≤100 vs. >100 g/week: adjusted OR = 0.542, p = 0.003). In this study, associations between ADIPOQ rs12495941, SIRT6 rs107251 and baPWV, as well as an interaction between SIRT6 rs107251 and soybean intake for different levels of baPWV were found. View Full-Text
Keywords: brachial ankle pulse wave velocity; atherosclerosis; genetic polymorphisms; inflammation; ADIPOQ; SIRT6; soybean; interaction brachial ankle pulse wave velocity; atherosclerosis; genetic polymorphisms; inflammation; ADIPOQ; SIRT6; soybean; interaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sun, K.; Xiang, X.; Li, N.; Huang, S.; Qin, X.; Wu, Y.; Tang, X.; Gao, P.; Li, J.; Wu, T.; Chen, D.; Hu, Y. Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity. Int. J. Mol. Sci. 2015, 16, 14338-14352.

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