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Int. J. Mol. Sci. 2015, 16(6), 13084-13105; doi:10.3390/ijms160613084

Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus

1
Department of Pathology and Center of Infection and Immunology, Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China
2
Department of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Chak-Sing Lau
Received: 27 April 2015 / Revised: 31 May 2015 / Accepted: 3 June 2015 / Published: 9 June 2015
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Abstract

Toll-like receptors (TLRs) are a large family of pattern recognition receptors. TLR signals are involved in the pathogenesis of systemic lupus erythematosus. Mouse and human B cells constitutively express most TLRs. Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells. The B cell-intrinsic TLR signals play critical roles during lupus process. In this review, roles of B cell-intrinsic TLR2, 4, 7, 8 and 9 signals are discussed during lupus pathogenesis in both mouse model and patients. Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted. View Full-Text
Keywords: toll-like receptor (TLR); systemic lupus erythematosus (SLE); anti-nuclear autoantibody (ANA); B-1 B cells; transitional B cells; marginal zone B cells (MZ B cells); germinal center B cells (GC B cells); memory B cells; myeloid differentiation primary response gene 88 (MyD88); Unc-93 Homolog B1 (C. elegans) (Unc93b1) toll-like receptor (TLR); systemic lupus erythematosus (SLE); anti-nuclear autoantibody (ANA); B-1 B cells; transitional B cells; marginal zone B cells (MZ B cells); germinal center B cells (GC B cells); memory B cells; myeloid differentiation primary response gene 88 (MyD88); Unc-93 Homolog B1 (C. elegans) (Unc93b1)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ma, K.; Li, J.; Fang, Y.; Lu, L. Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus. Int. J. Mol. Sci. 2015, 16, 13084-13105.

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