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Int. J. Mol. Sci. 2015, 16(6), 14158-14170; doi:10.3390/ijms160614158

A Plasmacytoid Dendritic Cells-Type I Interferon Axis Is Critically Implicated in the Pathogenesis of Systemic Lupus Erythematosus

1
Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 700-712, Korea
2
Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
3
Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Seoul 143-729, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Chak-Sing Lau
Received: 21 April 2015 / Revised: 1 June 2015 / Accepted: 16 June 2015 / Published: 23 June 2015
View Full-Text   |   Download PDF [922 KB, uploaded 23 June 2015]   |  

Abstract

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that is characterized by the generation of immune responses to various nuclear components. Impaired clearance of apoptotic cells and loss of tolerance to self-antigens are involved both in the initiation and in the propagation of the disease. Dendritic cells (DCs) are key factors in the balance between autoimmunity and tolerance and play a role linking innate and adaptive immunity. DCs, particularly plasmacytoid DCs (pDCs), are the main source of type I interferon (IFN) cytokines, which contribute to the immunopathogenesis of SLE. There is accumulating evidence that pDCs and type I IFN cytokines take the leading part in the development of SLE. In this review, we discuss recent data regarding the role of pDCs and type I IFN cytokines in the pathogenesis of SLE and the potential for employing therapies targeting against aberrant regulation of the pDC-type I IFN axis for treating SLE. View Full-Text
Keywords: systemic lupus erythematosus; dendritic cells; type I interferon systemic lupus erythematosus; dendritic cells; type I interferon
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Kim, J.-M.; Park, S.-H.; Kim, H.-Y.; Kwok, S.-K. A Plasmacytoid Dendritic Cells-Type I Interferon Axis Is Critically Implicated in the Pathogenesis of Systemic Lupus Erythematosus. Int. J. Mol. Sci. 2015, 16, 14158-14170.

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