The Neurocognitive Profile of the Cerebellum in Multiple Sclerosis
Abstract
:1. Introduction
2. Results
Article | MS Phenotype | No. of Subjects | Imaging Method | MRI Features | Neuropsychological Findings | Neuroimaging Findings |
---|---|---|---|---|---|---|
Valentino et al., 2009 | RR-MSc | 21 | Semi-automated morhpometry | Cerebellar and cortical TLL | RR-MSc: Deficits in SDMT and COWAT with respect to RR-MSnc | RR-MSc: No significant correlation between cognitive impairment and TLL |
RR-MSnc | 21 | |||||
Cerasa et al., 2012 | RR-MSc | 12 | Semi-automated morhpometry/fMRI task | Cerebellar TLL and volume | RR-MSc: Deficits in SDMT, ST and WLG with respect to controls | RR-MSc: Cerebellar TLL correlated with fMRI activity of the superior parietal lobule during PVSAT |
RR-MSnc | 15 | |||||
Controls | 16 | |||||
Cerasa et al., 2013 | RR-MSc | 12 | Semi-automated morhpometry/VBM | Cerebellar TLL and GM volume | RR-MSc: Deficits in SDMT, COWAT and ROCFT with respect to RR-MSnc and controls | RR-MSc: GM volume in the dorsolateral prefrontal cortex correlated with SDMT; GM volume in superior temporal gyrus correlated with COWAT |
RR-MSnc | 14 | |||||
Controls | 20 | |||||
Damasceno et al., 2014 | RR-MS | 42 | Semi-automated morhpometry/FreeSurfer | Cerebellar GM/WM volume, intracortical/leukocortical lesions (nr. and volume) | RR-MS: deficits in SDMT and PASAT with respect to controls | RR-MS: Cerebellar intracortical lesions associated with SDMT, Cerebellar leukocortical lesions associated with PASAT |
Controls | 30 | |||||
Rocca et al., 2014 | RR-MS | 121 | fMRI connectivity | Global and regional network properties, hubs | – | RR-MS: PASAT correlated with global network features, with absence of additional hubs in Lobule VII of right cerebellum, and with a decrease of nodal degree in right cerebellum |
B-MS | 45 | |||||
SP-MS | 80 | |||||
Romascano et al., 2014 | RR-MS | 28 | Automated morhpometry/fMRI connectivity | Cerebellar lesion (nr. and volume), CPN parameters: T1 rt, T2 rt, MTR, GFA | RR-MS: No cognitive deficit | RR-MS: T1 rt, T2 rt, GFA associated with the SRT-LTS, GFA correlated SRT-CLTR and SDMT, T2 rt correlated with SPART-D |
Controls | 26 | |||||
Weier et al., 2014 | RR-MSc | 120 | Semi-automated morhpometry/SIENAX | TCV, CGV, CWV | RR-MSc: Deficits in SDMT and PASAT with respect to RR-MSnc | RR-MSc: TCV correlated with SDMT, cerebellar T1 lesion volume significant predictor of PASAT |
RR-MSnc | 52 | |||||
Deppe et al., 2015 | RR-MS | 68 | DTI | Cerebellar FA, AD, MD, RD | – | RR-MS: Cerebellar FA correlated with motor disability scale (EDSS) |
Controls | 26 |
2.1. Valentino et al., 2009
2.2. Cerasa et al., 2012
2.3. Cerasa et al., 2013
2.4. Damasceno et al., 2014
2.5. Rocca et al., 2014
2.6. Romascano et al., 2014
2.7. Weier et al., 2014
2.8. Deppe et al., 2015
3. Discussion
4. Conclusions
Acknowledgments
Author Contributions
Abbreviations
9HPT | 9-Hole Peg Test |
B-MS | Benign MS |
BRB-N | Brief Repeatable Battery of Neuropsychological Tests |
COWAT | Controlled Oral Word Association Test |
DR | Delayed Recall |
DTI | Diffusion Tensor Imaging |
EDSS | Expanded Disability Status Scale |
FA | Fractional Anisotropy |
FSS | Fatigue Severity Scale |
GFA | Generalized Fractional Anisotropy |
GM | Grey Matter |
IR | Immediate Recall |
JLO | Judgment Line Orientation |
MCST CA | Modified Card Sorting Test Categories Achieved |
MCST PE | Modified Card Sorting Test Perseverative Errors |
MMSE | Mini Mental State Examination |
MS | Multiple Sclerosis |
PASAT | Paced Auditory Serial Addition Task |
PP-MS | Primary Progressive MS |
PVSAT | Paced Visual Serial Addition Test |
RAVLT | Rey Auditory-Verbal Learning Test |
Rec | Recognition of lists of words |
ROCFT | Rey-Osterrieth Complex Figure Test |
RR-MSc | Relapsing-remitting MS patients with cerebellar symptoms |
RR-MSnc | Relapsing-remitting MS patients without cerebellar symptoms |
SDMT | Symbol Digit Modalities Test |
SP-MS | Secondary Progressive MS |
SPART-I | Spatial Recall Test-Immediate |
SPART-D | Spatial Recall Test-Delayed |
SRT-LTS | Selective Reminding Test-Long Term Storage |
SRT-CLTR | Selective Reminding Test-Consistent Long Term Storage |
SRT-D | Selective Reminding Test-Delayed |
ST | Stroop task |
T25FW | Timed-25 Foot Walk test |
T2LL | T2-hyperintense lesion load |
TCV | Total Cerebellar Volume |
CGV | Cerebellar Grey matter Volume |
CWV | Cerebellar White matter Volume |
TLL | Total Lesion Load |
VBM | Voxel-based Morphometry |
WCST | Wisconsin Card Sorting Test |
WLG | Word List Generation test |
WM | White Matter |
Conflicts of Interest
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Sarica, A.; Cerasa, A.; Quattrone, A. The Neurocognitive Profile of the Cerebellum in Multiple Sclerosis. Int. J. Mol. Sci. 2015, 16, 12185-12198. https://doi.org/10.3390/ijms160612185
Sarica A, Cerasa A, Quattrone A. The Neurocognitive Profile of the Cerebellum in Multiple Sclerosis. International Journal of Molecular Sciences. 2015; 16(6):12185-12198. https://doi.org/10.3390/ijms160612185
Chicago/Turabian StyleSarica, Alessia, Antonio Cerasa, and Aldo Quattrone. 2015. "The Neurocognitive Profile of the Cerebellum in Multiple Sclerosis" International Journal of Molecular Sciences 16, no. 6: 12185-12198. https://doi.org/10.3390/ijms160612185