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Int. J. Mol. Sci. 2015, 16(5), 9469-9483; doi:10.3390/ijms16059469

Relationship between Proinflammatory and Antioxidant Proteins with the Severity of Cardiovascular Disease in Type 2 Diabetes Mellitus

1
Bone Metabolic Unit, Endocrinology Division (RETICEF), Instituto de Investigación Biosanitaria (Ibs) Granada, University Hospital San Cecilio, Granada 18012, Spain
2
Proteomic Research Service, Instituto de Investigación Biosanitaria (Ibs) Granada, University Hospital San Cecilio, Granada 18012, Spain
3
Proteomic Research Service, Institute of Parasitology and Biomedicine "López Neyra" (C.S.I.C.), Granada 18016, Spain
4
Endocrinology Division, Ciudad Real General Hospital, Ciudad Real 13005, Spain
5
Infectious Diseases Unit, Instituto de Investigación Biosanitaria (Ibs) Granada, University Hospital San Cecilio, Av. Dr. Olóriz 16, Granada 18012, Spain
6
Endocrinology Unit, University Hospital San Cecilio, Av. Dr. Olóriz 16, Granada 18012, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Francis Miller
Received: 26 February 2015 / Revised: 1 April 2015 / Accepted: 8 April 2015 / Published: 27 April 2015
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2015)
View Full-Text   |   Download PDF [1103 KB, uploaded 27 April 2015]   |  

Abstract

Type 2 diabetes mellitus patients are at significant risk of cardiovascular disease, however, the pathophysiology of these complications is complex and incompletely known in this population. The aim of this study was to compare the serum proteome of patients with type 2 diabetes mellitus presenting or not presenting cardiovascular disease with non-diabetic subjects to find essential proteins related to these cardiovascular complications. This cross-sectional study compares the serum proteome by a combination of protein depletion with 2D-DIGE (2-dimension Difference Gel Electrophoresis) methodology. The proteins differentially expressed were identified by MALDI TOF/TOF (Matrix-assisted laser desorption/ionization and Time-Of-Flight ion detector) or LC-MS/MS (Liquid Chromatography coupled to Mass-Mass Spectrometry). Type 2 diabetes mellitus patients with cardiovascular disease showed higher expression of plasma retinol binding protein and glutathione peroxidase-3 compared to those without cardiovascular disease and non-diabetic controls. These results show that proteins related to the inflammatory and redox state appear to play an important role in the pathogenesis of the cardiovascular disease in the type 2 diabetes mellitus patients. View Full-Text
Keywords: cardiovascular disease; type 2 diabetes mellitus; proinflammation; oxidative stress; proteomic cardiovascular disease; type 2 diabetes mellitus; proinflammation; oxidative stress; proteomic
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MDPI and ACS Style

García-Fontana, B.; Morales-Santana, S.; Longobardo, V.; Reyes-García, R.; Rozas-Moreno, P.; García-Salcedo, J.A.; Muñoz-Torres, M. Relationship between Proinflammatory and Antioxidant Proteins with the Severity of Cardiovascular Disease in Type 2 Diabetes Mellitus. Int. J. Mol. Sci. 2015, 16, 9469-9483.

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