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Int. J. Mol. Sci. 2015, 16(5), 9303-9313; doi:10.3390/ijms16059303

The Role of Food Peptides in Lipid Metabolism during Dyslipidemia and Associated Health Conditions

1
Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS B2N 5E3, Canada
2
Department of Plant and Animal Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS B2N 5E3, Canada
*
Author to whom correspondence should be addressed.
Received: 17 December 2014 / Revised: 10 April 2015 / Accepted: 20 April 2015 / Published: 24 April 2015
(This article belongs to the Special Issue Bioactive Proteins and Peptides Derived from Food)
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Abstract

Animal and human clinical studies have demonstrated the ability of dietary food proteins to modulate endogenous lipid levels during abnormal lipid metabolism (dyslipidemia). Considering the susceptibility of proteins to gastric proteolytic activities, the hypolipidemic functions of proteins are possibly due, in part, to their peptide fragments. Food-derived peptides may directly modulate abnormal lipid metabolism in cell cultures and animal models of dyslipidemia. The peptides are thought to act by perturbing intestinal absorption of dietary cholesterol and enterohepatic bile acid circulation, and by inhibiting lipogenic enzymatic activities and gene expression in hepatocytes and adipocytes. Recent evidence indicates that the hypolipidemic activities of some peptides are due to activation of hepatic lipogenic transcription factors. However, detailed molecular mechanisms and structural requirements of peptides for these activities are yet to be elucidated. As hypolipidemic peptides can be released during enzymatic food processing, future studies can explore the prospects of combating metabolic syndrome and associated complications using peptide-rich functional food and nutraceutical products. View Full-Text
Keywords: bioactive peptides; hyperlipidemia; metabolic syndrome; cardiovascular disease; lipogenesis; hepatocytes; adipose tissue; hepatic steatosis bioactive peptides; hyperlipidemia; metabolic syndrome; cardiovascular disease; lipogenesis; hepatocytes; adipose tissue; hepatic steatosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Udenigwe, C.C.; Rouvinen-Watt, K. The Role of Food Peptides in Lipid Metabolism during Dyslipidemia and Associated Health Conditions. Int. J. Mol. Sci. 2015, 16, 9303-9313.

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