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Int. J. Mol. Sci. 2015, 16(5), 9152-9166; doi:10.3390/ijms16059152

Expression Profiling Reveals Genes Involved in the Regulation of Wool Follicle Bulb Regression and Regeneration in Sheep

1
Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China
2
College of Animal Science, South China Agricultural University, Guangzhou 510642, China
3
College of Animal Science, Agriculture and Animal Husbandry College of Tibet, Linzhi, Tibet 860000, China
*
Author to whom correspondence should be addressed.
Academic Editor: Ritva Tikkanen
Received: 28 January 2015 / Revised: 8 April 2015 / Accepted: 10 April 2015 / Published: 23 April 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Wool is an important material in textile manufacturing. In order to investigate the intrinsic factors that regulate wool follicle cycling and wool fiber properties, Illumina sequencing was performed on wool follicle bulb samples from the middle anagen, catagen and late telogen/early anagen phases. In total, 13,898 genes were identified. KRTs and KRTAPs are the most highly expressed gene families in wool follicle bulb. In addition, 438 and 203 genes were identified to be differentially expressed in wool follicle bulb samples from the middle anagen phase compared to the catagen phase and the samples from the catagen phase compared to the late telogen/early anagen phase, respectively. Finally, our data revealed that two groups of genes presenting distinct expression patterns during the phase transformation may have important roles for wool follicle bulb regression and regeneration. In conclusion, our results demonstrated the gene expression patterns in the wool follicle bulb and add new data towards an understanding of the mechanisms involved in wool fiber growth in sheep. View Full-Text
Keywords: hair follicle; wool; sheep; gene expression profiling; high-throughput RNA sequencing hair follicle; wool; sheep; gene expression profiling; high-throughput RNA sequencing
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Liu, G.; Liu, R.; Tang, X.; Cao, J.; Zhao, S.; Yu, M. Expression Profiling Reveals Genes Involved in the Regulation of Wool Follicle Bulb Regression and Regeneration in Sheep. Int. J. Mol. Sci. 2015, 16, 9152-9166.

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