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Int. J. Mol. Sci. 2015, 16(5), 10537-10561; doi:10.3390/ijms160510537

Cyanobacterial Hydrogenases and Hydrogen Metabolism Revisited: Recent Progress and Future Prospects

Microbial Chemistry, Department of Chemistry—Ångström Laboratory, Uppsala University, Box 523, Uppsala SE-75120, Sweden
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Academic Editor: Patrick Hallenbeck
Received: 11 March 2015 / Revised: 29 April 2015 / Accepted: 30 April 2015 / Published: 8 May 2015
(This article belongs to the Special Issue Photosynthesis and Biological Hydrogen Production)
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Abstract

Cyanobacteria have garnered interest as potential cell factories for hydrogen production. In conjunction with photosynthesis, these organisms can utilize inexpensive inorganic substrates and solar energy for simultaneous biosynthesis and hydrogen evolution. However, the hydrogen yield associated with these organisms remains far too low to compete with the existing chemical processes. Our limited understanding of the cellular hydrogen production pathway is a primary setback in the potential scale-up of this process. In this regard, the present review discusses the recent insight around ferredoxin/flavodoxin as the likely electron donor to the bidirectional Hox hydrogenase instead of the generally accepted NAD(P)H. This may have far reaching implications in powering solar driven hydrogen production. However, it is evident that a successful hydrogen-producing candidate would likely integrate enzymatic traits from different species. Engineering the [NiFe] hydrogenases for optimal catalytic efficiency or expression of a high turnover [FeFe] hydrogenase in these photo-autotrophs may facilitate the development of strains to reach target levels of biohydrogen production in cyanobacteria. The fundamental advancements achieved in these fields are also summarized in this review. View Full-Text
Keywords: biohydrogen; bidirectional Hox hydrogenase; cyanobacteria; ferredoxin; [FeFe] hydrogenase; [NiFe] hydrogenase biohydrogen; bidirectional Hox hydrogenase; cyanobacteria; ferredoxin; [FeFe] hydrogenase; [NiFe] hydrogenase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Khanna, N.; Lindblad, P. Cyanobacterial Hydrogenases and Hydrogen Metabolism Revisited: Recent Progress and Future Prospects. Int. J. Mol. Sci. 2015, 16, 10537-10561.

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