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Int. J. Mol. Sci. 2015, 16(5), 10158-10172; doi:10.3390/ijms160510158

The Heart Protection Effect of Alcalase Potato Protein Hydrolysate Is through IGF1R-PI3K-Akt Compensatory Reactivation in Aging Rats on High Fat Diets

1
PhD Program for Aging, China Medical University, Taichung 40402, Taiwan
2
Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan
3
Department of Food Science, College of Agriculture, Tunghai University, Taichung 40704, Taiwan
4
Division of Cardiology, China Medical University Hospital, Taichung 40402, Taiwan
5
Department of Pathology, Changhua Christian Hospital, Changhua 50006, Taiwan
6
Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 35664, Taiwan
7
Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan Town 35053, Taiwan
8
Department of Hospitality Management, College of Agriculture, Tunghai University, Taichung 40704, Taiwan
9
Graduate Institute of Chinese Medical Science, China Medical University, Taichung 40402, Taiwan
10
Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 12 March 2015 / Revised: 21 April 2015 / Accepted: 23 April 2015 / Published: 5 May 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [4327 KB, uploaded 5 May 2015]   |  

Abstract

The prevalence of obesity is high in older adults. Alcalase potato protein hydrolysate (APPH), a nutraceutical food, might have greater benefits and be more economical than hypolipidemic drugs. In this study, serum lipid profiles and heart protective effects were evaluated in high fat diet (HFD) induced hyperlipidemia in aging rats treated with APPH (15, 45 and 75 mg/kg/day) and probucol (500 mg/kg/day). APPH treatments reduced serum triacylglycerol (TG), total cholesterol (TC), and low density lipoprotein (LDL) levels to the normal levels expressed in the control group. Additionally, the IGF1R-PI3K-Akt survival pathway was reactivated, and Fas-FADD (Fas-associated death domain) induced apoptosis was inhibited by APPH treatments (15 and 45 mg/kg/day) in HFD aging rat hearts. APPH (75 mg/kg/day) rather than probucol (500 mg/kg/day) treatment could reduce serum lipids without affecting HDL expression. The heart protective effect of APPH in aging rats with hyperlipidemia was through lowering serum lipids and enhancing the activation of the compensatory IGF1R-PI3K-Akt survival pathway. View Full-Text
Keywords: hyperlipidemia; alcalase potato protein hydrolysate; aging hyperlipidemia; alcalase potato protein hydrolysate; aging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hu, W.-S.; Ting, W.-J.; Chiang, W.-D.; Pai, P.; Yeh, Y.-L.; Chang, C.-H.; Lin, W.-T.; Huang, C.-Y. The Heart Protection Effect of Alcalase Potato Protein Hydrolysate Is through IGF1R-PI3K-Akt Compensatory Reactivation in Aging Rats on High Fat Diets. Int. J. Mol. Sci. 2015, 16, 10158-10172.

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