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Int. J. Mol. Sci. 2015, 16(4), 8102-8109; doi:10.3390/ijms16048102

Anti-Inflammatory Effect of Emodin via Attenuation of NLRP3 Inflammasome Activation

1
Department of Biotechnology, College of Biomedical & Health Science, Research Institute of Inflammatory Diseases, Konkuk University, Chungju 380-701, Korea
2
Department of Food Science & Technology, Korea National University of Transportation, Chungju 368-701, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 7 February 2015 / Revised: 31 March 2015 / Accepted: 1 April 2015 / Published: 10 April 2015
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Abstract

Emodin, an active constituent of oriental herbs, is widely used to treat allergy, inflammation, and other symptoms. This study provides the scientific basis for the anti-inflammasome effects of emodin on both in vitro and in vivo experimental models. Bone marrow-derived macrophages were used to study the effects of emodin on inflammasome activation by using inflammasome inducers such as ATP, nigericin, and silica crystals. The lipopolysaccharide (LPS)-induced endotoxin shock model was employed to study the effect of emodin on in vivo efficacy. Emodin treatment attenuated interleukin (IL)-1β secretion via the inhibition of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation induced by ATP, nigericin, and silica crystals. Further, emodin ameliorated the severity of NLRP3 inflammasome-mediated symptoms in LPS-induced endotoxin mouse models. This study is the first to reveal mechanism-based evidence, especially with respect to regulation of inflammasome activation, substantiating traditional claims of emodin in the treatment of inflammation-related disorders. View Full-Text
Keywords: emodin; interleukin (IL)-1β; NLRP3 inflammasome; sepsis emodin; interleukin (IL)-1β; NLRP3 inflammasome; sepsis
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MDPI and ACS Style

Han, J.-W.; Shim, D.-W.; Shin, W.-Y.; Heo, K.-H.; Kwak, S.-B.; Sim, E.-J.; Jeong, J.-H.; Kang, T.-B.; Lee, K.-H. Anti-Inflammatory Effect of Emodin via Attenuation of NLRP3 Inflammasome Activation. Int. J. Mol. Sci. 2015, 16, 8102-8109.

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